UTMB OAIC Metabolism and Biology Resource Core 1 (MBRC1)

项目摘要/摘要(MBRC1) UTMB OAIC代谢和生物资源核心(MBRC1)促进和支持基础科学和 与OAIC主题相关的翻译研究，即将功能丧失和获得的途径翻译成 干预措施，以优化不同老年人群的功能恢复。MBRC1对以下方面至关重要 UTMB OAIC的成功，支持了肌肉衰老机制的许多关键发现 和骨质疏松症。在本周期内，它支持了21笔国立卫生研究院赠款、11笔其他外部赠款和12笔对外援助。 项目。 MBRC1的具体目标是： 1.为OAIC研究提供分析支持和增值。 2.发展研究功能丧失和恢复机制的新方法。 3.对早期研究人员进行基础科学和方法学方面的分析和方法方面的培训 关于老年人功能丧失、获得和恢复的翻译研究。 MBRC1支持有关骨质疏松症、身体功能障碍和康复需求的基础和翻译研究 代谢表型、分子生物学技术、示踪方法学、动物模型和细胞培养。它 提供必要的工具来确定发生在全身、组织和细胞的动态变化 老年人的代谢水平；量化年龄、疾病、不活动和合成代谢干预的代谢影响； 并确定这些变化背后的基本机制。MBRC1还促进了 分子、细胞和示踪方法在动物和人类的个体实验中发现 老年人特殊病理生理反应的机制。它还进化到 通过开发生物库和样本服务，支持下一步的翻译-大型临床试验 加工和运输。 在下一个周期中，MBRC1将扩展分子代谢资源并支持反向翻译 通过进一步开发和利用可诱导的肌肉特异性基因敲除小鼠模型，结合 示踪方法，开发治疗骨质疏松症的新疗法，并提供进入机构的途径 向OAIC研究人员提供代谢组和转录组资源。它还将继续为以下方面提供资源 早期调查人员和伊斯兰会议组织试点研究，协助生成和利用初步数据 用于竞争性拨款申请。

PROJECT SUMMARY/ABSTRACT (MBRC1) The UTMB OAIC Metabolism and Biology Resource Core (MBRC1) promotes and supports basic science and translational research relevant to the OAIC theme which is Translate pathways of functional loss and gain into interventions to optimize functional recovery in diverse geriatric populations. The MBRC1 has been critical to the success of the UTMB OAIC, having supported many key discoveries on the mechanisms of muscle aging and sarcopenia. In the current cycle, it has supported 21 NIH grants, 11 other external grants, and 12 OAIC projects. The MBRC1 specific aims are: 1. Provide analytical support and add value to OAIC research. 2. Develop new methods to study the mechanisms of functional loss and recovery. 3. Train early-stage investigators on the analytical and methodological aspects of basic science and translational research on functional loss, gain and recovery in older adults. MBRC1 supports basic and translational research on sarcopenia, physical dysfunction and recovery requiring metabolic phenotyping, molecular biology techniques, tracer methodologies, animal models and cell cultures. It provides essential tools to determine the dynamic changes that occur at the whole-body, tissue and cellular levels in older individuals; quantify the metabolic effects of age, disease, inactivity and anabolic interventions; and determine the basic mechanisms that underlie these changes. MBRC1 also promotes integration of molecular, cellular and tracer methodologies within individual experiments in animals and humans to discover the mechanisms that underlie specific pathophysiological responses in older adults. It has also evolved to support the next step in translation – large clinical trials – by developing a biobank and services for sample processing and shipping. Over the next cycle, MBRC1 will expand the molecular metabolism resources and support reverse translation by further developing and utilizing inducible muscle specific knockout mouse models, integrating the use of traceromic methods, developing novel therapeutics for sarcopenia, and providing access to institutional metabolomic and transcriptomic resources to OAIC investigators. It will also continue to provide resources for early-stage investigators and OAIC pilot studies, assisting in the generation and utilization of preliminary data for competitive grant applications.