MoTrPAC Consortium Coordinating Center

摘要 缺乏体育活动是所有年龄段广泛健康问题背后的一个重大公共卫生挑战。 虽然体力活动(PA)已被证明能产生相关的健康益处，但潜在的分子 人们对此知之甚少。临床和动物研究的协调努力由 生物信息学和化学分析将实现生理活性联盟的分子传感器 (MoTrPAC)评估因PA而发生的分子变化的目标。财团 MoTrPAC的协调中心(CCC)将为组织、管理、规划、 与MoTrPAC有关的标准化、文件编制、监测和报告活动。中国职业棒球大联盟将在 通过加强所有各方的沟通和整合，确保MoTrPAC的凝聚力方面发挥关键作用 研究部分，包括临床站点、临床前动物研究站点、生物信息学中心、 化学分析站点和各种研究委员会。协调中心将制定战略和战略 通过将MoTrPAC调查人员的活动与数据提供的输入相结合来规划流程 安全监测委员会、外部科学顾问、外部专家和美国国家卫生研究院。中央协调中心将协助 与财团外的初级和高级调查人员进行互动和沟通，以最大限度地提高 利用MoTrPAC资源实现总体研究目标。为了实现这些目标并 最大限度地提高MoTrPAC的进步和生产力，CCC将促进团队科学、团队领导力、 和创新的领导力方法，涵盖所有研究组成部分。遵循以下的战略规划 将培养动态战略理论的原则，以评估替代方法，维护 聚焦尖端科学，利用最先进的协调技术，预测挑战，以及 最大限度地扩大未来的机会，以确保财团的成功。协调中心将由四个综合 由四名高素质的PI领导的组件，他们拥有长期的成功工作记录 协同效应。CCC的四个组成部分包括行政协调中心(PI博士Pahor)、数据 管理、分析和质量控制中心(Pi Dr.Miller)、生物检疫库(Pi Dr.Tracy)、 和运动干预核心(PI博士Rejeski)。协调中心将采用创新的项目管理工具 以及基于网络的运动依从性和饮食跟踪，并将利用出色的记录和 其调查人员在以下方面的专长：(A)合作；(B)成功地协调、管理和领导 涉及PA和其他干预措施的大型长期多中心临床试验；(C)实施严谨和 研究的透明度；(D)获取、管理、储存和分析生物样本；(E)进行 动物运动研究；(F)共享资源；(G)发布结果；(H)领导多学科团队。 协调中心将确保和促进MoTrPAC继续成功地促进对 对PA作出反应而发生的分子变化，并将这些变化与PA的健康益处联系起来。

Summary Physical inactivity is a major public health challenge underlying a broad range of health problems at all ages. While physical activity (PA) has shown to produce relevant health benefits, the underlying molecular mechanisms are poorly known. The coordinated effort of clinical and animal studies supported by bioinformatics and chemical analyses will achieve the Molecular Transducers of Physical Activity Consortium (MoTrPAC) goals of assessing the molecular changes that occur in response to PA. The Consortium Coordinating Center (CCC) for the MoTrPAC will provide support for the organization, administration, planning, standardization, documentation, monitoring and reporting activities relating to the MoTrPAC. The CCC will play a pivotal role in ensuring the cohesion of the MoTrPAC by enhancing communication and integration across all study components, including the Clinical Sites, the Preclinical Animal Study Sites, the Bioinformatics Center, the Chemical Analysis Sites, and the various study committees. The CCC will develop strategies and strategic planning processes by integrating activities of the MoTrPAC investigators with the input provided by the Data Safety Monitoring Board, the External Scientific Advisors, outside experts, and the NIH. The CCC will facilitate interactions and communications with junior and senior investigators outside the consortium to maximize the use of the MoTrPAC resources toward achieving the overall research goals. To accomplish these goals and maximize the progress and productivity of the MoTrPAC, the CCC will promote team science, team leadership, and innovative leadership approaches across all study components. Strategic planning that follows the principles of the dynamic theory of strategy will be fostered to evaluate alternative approaches, maintain the cutting-edge scientific focus, leverage state-of-the-art coordination technologies, anticipate challenges, and maximize future opportunities to ensure the success of the consortium. The CCC will comprise four integrated components led by four highly qualified PIs who have a long-lasting track record of successfully working in synergy. The four CCC components comprise the Administrative Coordinating Center (PI Dr. Pahor), the Data Management, Analysis, and Quality Control Center (PI Dr. Miller), the Biospecimens Repository (PI Dr. Tracy), and the Exercise Intervention Core (PI Dr. Rejeski). The CCC will employ innovative project management tools and web-based tracking of exercise adherence and diet, and will capitalize on the outstanding track record and expertise of its investigators in: (a) working together; (b) successfully coordinating, managing, and leading large long-term multicenter clinical trials involving PA and other interventions; (c) implementing rigor and transparency in research, (d) acquiring, managing, storing and analyzing biological samples; (e) conducting animal exercise studies; (f) sharing resources; (g) publishing results; and (h) leading multidisciplinary teams. The CCC will ensure and promote the continued success of the MoTrPAC in advancing knowledge about the molecular changes that occur in response to PA, and relating these changes to the health benefits of PA.