HOPE Training Grant

项目总结/摘要 艾滋病毒和SARS-CoV-2病毒大流行对全球的持续影响以及 疾病的管理和预防需要培训和培养有才能的新研究人员。 自1990年以来，我们在加州大学圣地亚哥分校（UCSD）培养博士后学者。 该计划旨在培养能够独立领导有影响力的新调查人员 研究基础和转化病毒生物学和发病机制。本申请建议更新本 非常成功的培训计划。根据我们的战略规划过程，我们建议扩大 该计划的范围，以更好地反映艾滋病研究办公室的研究重点，并回应 新冠肺炎等病毒大流行的挑战。具体来说，该计划的优先事项将包括减少发病率 （包括疫苗接种）、治疗方法和治愈、健康差异和长期合并症。以反映这一 扩大，我们提出了一个新的领导结构，已经发展到我们的教师23导师谁拥有广泛的 独立研究，合作和培训的历史。我们已经重命名了应用程序以反映这些 变化，艾滋病毒和其他PandEmics，或希望。我们还增加了10名发展中的导师（MiD），他们 是一个内部人才库，新一代的职业生涯中期导师为希望培训计划 会随着时间的推移而发展。教师致力于识别有才华和承诺的博士后学员， 提供环境和机会，支持他们在医学相关领域实现独立 基础、转化、临床和流行病学研究。 该计划将保留其成功的教育和培训元素，同时结合创新的新 提供解决现代医学和公共卫生面临的最大挑战之一，SARS-CoV-2。 我们教师的研究兴趣和活动支持病毒学研究的不断发展的重点和优先事项 特别是在我们的项目中。我们建议资助6名博士后学员进行培训， 每两年至三年。我们的目标是继续改善我们在培训代表性不足方面的成功 少数民族和妇女。通过我们的密切指导，受训者驱动的研究，互动研究计划 审查和职业发展活动，我们的首要目标仍然是准备下一代 科学家在生物医学研究具有地方，国家和国际影响的高生产力的职业生涯。

PROJECT SUMMARY/ABSTRACT The sustained global impact of the viral pandemics of HIV and SARS-CoV-2 and the challenges to the management and prevention of disease require the training and development of talented new researchers. Since 1990, we trained postdoctoral scholars in this program at the University of California, San Diego (UCSD). The program is designed to produce new investigators who are capable of independently leading impactful research in basic and translational viral biology and pathogenesis. This application proposes renewal of this highly successful training program. Based on our strategic planning process, we propose an expansion in the program’s scope to better reflect the research priorities of the Office of AIDS Research and to respond to the challenges of viral pandemics like COVID-19. Specifically, the program’s priorities will include reducing incidence (including vaccination), therapeutics and cure, health disparities, and long-term comorbidities. To reflect this expansion, we propose a new leadership structure, have grown our faculty to 23 mentors who have an extensive history of independent research, collaborations, and training. We have renamed the application to reflect these changes, HIV and Other PandEmics, or HOPE. We have also added 10 mentors-in-development (MiDs), who are an internal talent pool from which a new generation of mid-career mentors for the HOPE Training Program will develop over time. The faculty are committed to identifying talented and committed postdoctoral trainees and to providing the environment and opportunities that will support their path to independence in medically relevant basic, translational, clinical, and epidemiological research. The program will retain its successful educational and training elements, while incorporating innovative new offerings to address one of the greatest challenges facing modern medicine and public health, SARS-CoV-2. The research interests and activities of our faculty support the evolving focus and priorities of virology research in general and specifically within our program. We propose to support six postdoctoral trainees for a training period of two to three years each. We aim to continue to improve on our success in training underrepresented minorities and women. Through our program of closely mentored, trainee-driven research, interactive research review, and career development activities, our overarching goal remains to prepare the next generation of scientists for highly productive careers in biomedical research with local, national and international impact.