Core A Admin

管理核心-核心A：项目概要/摘要 BIOCARD研究是对349名认知正常的个体进行的纵向观察性研究， 入组时主要为中年（平均年龄=57.1岁）。这些受试者现在已经被随访了27年。 该项目的总体目标是进一步推进临床前阿尔茨海默病的研究 通过：（1）阐明AD生物标志物（包括基于CSF，血液，MRI， 和PET成像）和认知;待研究的生物标志物包括几种有前途的新型生物标志物 血液脑脊液和脑成像的结果(2)最大化我们的数据，通过与多个 拥有可比数据的研究小组，以及（3）提供可公开访问的数据，大脑扫描，以及 生物标本，供该领域的研究人员使用。为了实现这些目标，我们建立了7个核心， 本申请还包括2个项目。行政核心（核心A）负责 项目的整体运作和协调。具体目标包括：（1）监督和整合 （2）协助受试者保留和监督招募 额外的参与者，（3）与约翰霍普金斯大学以外的研究者合作，（4）保证 健全的财政管理，（5）保证项目的各个方面符合地方和联邦 （6）通过科学咨询委员会会议协调对项目的外部审查 和资源分配委员会，以及（7）与国家老龄问题研究所的工作人员沟通 关于研究的进展

ADMINISTRATIVE CORE – CORE A: PROJECT SUMMARY/ABSTRACT The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and primarily middle aged (mean age=57.1) at enrollment. The subjects have now been followed for up to 27 years. The overall objectives of the project are to further advance the study of preclinical Alzheimer’s disease by: (1) clarifying the pattern and rate of change in AD biomarkers (including those based on CSF, blood, MRI, and PET imaging) and cognition; the biomarkers to be studied include several promising novel biomarkers derived from blood, CSF and brain imaging. (2) maximizing our data by working collaboratively with several research groups who have comparable data, and (3) providing a publicly accessible data, brain scans, and biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores and, with this application, are also including 2 projects. The Administrative Core (Core A) is responsible for the overall functioning and coordination of the project. The specific aims include: (1) oversight and integration of the Cores and the Projects, (2) assistance with subject retention and oversight of the recruitment of additional participants, (3) collaboration with investigators outside of Johns Hopkins University, (4) assurance of sound fiscal management, (5) assurance that all aspects of the project comply with local and federal regulations, (6) coordinating external review of the project through meetings of the Scientific Advisory Board and the Resource Allocation Committee, and (7) communicating with the staff of the National Institute on Aging about the progress of the study.