HOPE Training Grant

项目摘要/摘要 艾滋病毒和SARS-CoV-2病毒大流行对全球的持续影响以及对 疾病的管理和预防需要培训和发展有才华的新研究人员。 自1990年以来，我们在加州大学圣地亚哥分校(UCSD)培训了这一项目的博士后学者。 该计划旨在培养能够独立领导有影响力的新的调查人员 基础和翻译病毒生物学和致病机理的研究。此应用程序建议续订此 非常成功的培训计划。根据我们的战略规划过程，我们建议在 方案的范围，以更好地反映艾滋病研究办公室的研究优先事项，并对 新冠肺炎等病毒大流行的挑战。具体地说，该计划的优先事项将包括减少发病率 (包括接种疫苗)、治疗和治愈、健康差距和长期并存。以反映这一点 扩展，我们提出了一个新的领导结构，我们的教职员工已经发展到23名导师，他们拥有广泛的 独立研究、合作和培训的历史。我们已重命名该应用程序以反映这些内容 变化，艾滋病毒和其他流行病，还是希望。我们还增加了10名发展中导师(MID)，他们 是内部人才库，希望培训计划的新一代职业中期导师 会随着时间的推移而发展。教职员工致力于发掘有才华的博士后实习生和 为他们提供环境和机会，支持他们在医学上独立的道路 基础研究、翻译研究、临床研究和流行病学研究。 该计划将保留其成功的教育和培训元素，同时纳入创新的新 为应对现代医学和公共卫生面临的最大挑战之一--SARS-CoV-2而提供的服务。 我们教员的研究兴趣和活动支持了病毒学研究的不断发展的重点和优先事项 总的来说，特别是在我们的计划内。我们建议支持六名博士后实习生进行培训 每项为期两至三年。我们的目标是继续改进我们在培训任职人数不足方面取得的成功 少数族裔和女性。通过我们的项目密切指导，学员驱动的研究，互动研究 回顾和职业发展活动，我们的首要目标仍然是为下一代 科学家在具有地方、国家和国际影响的生物医学研究领域从事高生产率的职业。

PROJECT SUMMARY/ABSTRACT The sustained global impact of the viral pandemics of HIV and SARS-CoV-2 and the challenges to the management and prevention of disease require the training and development of talented new researchers. Since 1990, we trained postdoctoral scholars in this program at the University of California, San Diego (UCSD). The program is designed to produce new investigators who are capable of independently leading impactful research in basic and translational viral biology and pathogenesis. This application proposes renewal of this highly successful training program. Based on our strategic planning process, we propose an expansion in the program’s scope to better reflect the research priorities of the Office of AIDS Research and to respond to the challenges of viral pandemics like COVID-19. Specifically, the program’s priorities will include reducing incidence (including vaccination), therapeutics and cure, health disparities, and long-term comorbidities. To reflect this expansion, we propose a new leadership structure, have grown our faculty to 23 mentors who have an extensive history of independent research, collaborations, and training. We have renamed the application to reflect these changes, HIV and Other PandEmics, or HOPE. We have also added 10 mentors-in-development (MiDs), who are an internal talent pool from which a new generation of mid-career mentors for the HOPE Training Program will develop over time. The faculty are committed to identifying talented and committed postdoctoral trainees and to providing the environment and opportunities that will support their path to independence in medically relevant basic, translational, clinical, and epidemiological research. The program will retain its successful educational and training elements, while incorporating innovative new offerings to address one of the greatest challenges facing modern medicine and public health, SARS-CoV-2. The research interests and activities of our faculty support the evolving focus and priorities of virology research in general and specifically within our program. We propose to support six postdoctoral trainees for a training period of two to three years each. We aim to continue to improve on our success in training underrepresented minorities and women. Through our program of closely mentored, trainee-driven research, interactive research review, and career development activities, our overarching goal remains to prepare the next generation of scientists for highly productive careers in biomedical research with local, national and international impact.