High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans

居家大强度间歇训练对老年退伍军人复原力的影响 超过30%的65岁或以上的美国退伍军人身体虚弱，这一比例是美国的三倍 同年龄段的非退伍军人。脆弱的定义是对由此产生的压力源的敏感性增加。 适应生物系统中与年龄相关的损害，导致不良后果的风险更高 包括跌倒、残疾、住院和死亡。此外，虚弱的患病率随着年龄的增长而增加， 影响到所有85岁及以上成年人的50%。恢复力，定义为从 应激诱导的动态平衡破坏是成功衰老的关键，因为它先于脆弱和 提供了一个干预早期健康缺陷的机会，从而防止与老龄化有关的 健康、功能和生活质量。增强老年人恢复力的循证疗法包括 复原力的有限和复杂的生物学和生理机制还不完全 明白了。因此，寻求提高自己从晚年压力中恢复的能力的退伍军人 预防脆弱几乎没有经过验证的选择。我们的首要目标是描述复杂的因素 促进复原力并制定新的战略，以增强复原力以提高健康寿命 上了年纪的人。为此，我们之前的VA RR&D尖顶奖允许我们展示 在老年退伍军人中进行为期12周的高强度间歇训练的可行性。我们成功地 招募和保留年长的男性和女性退伍军人，并安全地进行个人定制的HIIT 改善心肺健康、下半身耐力、认知和生活质量。目的 拟议的更大规模的试验的目的是在我们以往成功的基础上，开发和实施切实可行的 HIIT养生法以减少老年退伍军人的虚弱和增强复原力。我们将进行一次随机的 以中心和家庭为基础的12周HIIT治疗效果的对照试验 60岁或以上退伍军人的康复和复原力。我们已经确定了一系列生物标志物 并正在寻求在分子水平上研究复苏的关键生物驱动因素。我们的 拟议的研究不仅将确定衡量老年退伍军人复原力的可行方法，而且将 还要评估居家HIIT对身体和认知表现、脆弱、弹性、 和健康寿命。

Impact of Home-Based High Intensity Interval Training on Resilience in Older Veterans More than 30% of U.S. Veterans 65 years or older are frail, which is three-times higher than in non-Veterans in the same age group. Frailty is defined as an increased susceptibility to stressors resulting from age-related impairments in adaptive biological systems, leading to higher risk of adverse outcomes including falls, disability, hospitalization, and mortality. Further, frailty prevalence increases with age, affecting 50% of all adults 85 and over. Resilience, which is defined as the capacity to recover from stress-induced disruptions to homeostasis, is critical to successful aging because it precedes frailty and presents an opportunity to intervene on early health deficits, thus preventing aging-related decline in health, function, and quality of life. Evidence-based therapies that enhance resilience in older adults are limited and the complex biological and physiological mechanisms underlying resilience are not yet fully understood. Consequently, Veterans seeking to boost their ability to recover from late-life stressors and prevent frailty have few proven options. Our overarching aim is to characterize the complex factors contributing to resilience and develop novel strategies that enhance resilience to boost healthspan in older adults. Towards this end, our previous VA RR&D SPiRE Award allowed us to demonstrate the feasibility of 12-weeks of high intensity interval training (HIIT) among older Veterans. We successfully enrolled and retained older male and female Veterans and safely conducted individually tailored HIIT that improved cardiorespiratory fitness, lower-body endurance, cognition, and quality of life. The purpose of the proposed larger trial is to build upon our previous successes and develop and implement practical HIIT regimens to reduce frailty and enhance resilience in older Veterans. We will conduct a randomized controlled trial to ascertain the therapeutic benefits of 12-weeks of center- and home-based HIIT on recovery and resilience among Veterans 60 years or older. We have identified a series of biomarkers of resilience and are also seeking to examine key biological drivers of recovery at the molecular level. Our proposed study will not only identify feasible methods to measure resilience in older Veterans but will also assess the benefits of home-based HIIT on physical and cognitive performance, frailty, resilience, and healthspan.