Integrative Pathways to Health and Illness

摘要- Midus总体报告 美国中年人（Midlife in the U.S.，MIDUS）国家纵向研究自1995年以来一直在进行。MIDUS是唯一 一项全国性研究侧重于中年人，基线年龄跨度很大。MIDUS也有不寻常的深度， 社会心理学、生物标志物、基因组学和神经科学评估，从而可以关注神经生物学 社会人口和心理社会因素影响发病率的机制和途径， mortality.此应用程序旨在对MIDUS Refresher样本进行第二波数据收集 (MR2)以及对核心样本（M4）的第四波数据收集，包括两者中的所有项目。四 项目（调查，每日日记，生物标志物，基因组学）是U19竞争延续申请的一部分， 这与阿尔茨海默病（AD）和相关痴呆症（ADRD）的辅助U 01应用程序有关 这将研究中年对认知能力下降，情绪调节，大脑老化的影响，以及它们之间的相互作用。 以前的大部分工作也是纵向的，尽管它现在包括新的ADRD神经科学和生物标志物。 总体而言，拟议的活动涉及5，200多名美国成年人，这些活动将得到行政核心的支持 负责协调跨项目的数据收集，并提供高质量的、记录良好的数据; a BioCore确保生物标志物数据收集的质量控制，并提供生物标志物使用指南; 和统计核心，提供多个主题的研讨会（建模纵向变化，使用基因组 数据，将MIDUS链接到其他数据集）。拟议科学中反复出现的科学主题是健康 利用MIDUS提供的丰富的生物心理社会数据对不平等和种族差异进行研究，包括 对多个波的压力暴露进行广泛评估，从而提供 累积的逆境MIDUS还以其对心理社会和 行为保护因素，从而推进面对挑战的复原力研究。在A上老化 不断变化的历史阶段是MIDUS的另一个关键主题，这一主题体现在过去对 大衰退，展望未来，新的平行重点是COVID-19大流行的困难。方面 MIDUS是美国国家档案馆下载最频繁的研究， 计算机化老龄化数据（NACDA）。科学界的广泛使用（26，000+公众 用户）的出版物共计1 617份，涉及38个实质性领域。强调势头 在MIDUS之后，这些产品中有一半以上是在当前资助周期内发表的期刊文章 （2016年至今）。

ABSTRACT – MIDUS OVERALL PLAN The Midlife in the U.S. (MIDUS) national longitudinal study has been ongoing since 1995. MIDUS is the only national study focused on midlife with a wide age expanse at baseline. MIDUS also has unusual depth in its psychosocial, biomarker, genomic, and neuroscience assessments, thus permitting a focus on neurobiological mechanisms and pathways through which sociodemographic and psychosocial factors influence morbidity and mortality. This application aims to conduct a 2nd wave of data collection on the MIDUS Refresher sample (MR2) as well as a 4th wave of data collection on the Core sample (M4), including all projects in both. Four projects (Survey, Daily Diary, Biomarkers, Genomics) are part of this U19 competing continuation application, which is linked with an Ancillary U01 application on Alzheimer’s Disease (AD) and Related Dementias (ADRD) that will examine midlife precursurs to cognitive decline, emotion regulation, brain aging, and their interplay. Much of that prior work is also longitudinal, although it now includes new ADRD neuroscience and biomarkers. Overall, the proposed activities involve over 5,200 U.S. adults that will be supported by an Administrative Core responsible for orchestrating cross-project data collection and delivering high-quality, well-documented data; a BioCore that ensures quality control in biomarker data collection and offers guidance on use of biomarkers; and a Statistics Core that provides workshops on multiple topics (modeling longitudinal change, using genomic data, linking MIDUS to other datasets). Recurring scientific themes in the proposed science are health inequalities and racial disparities examined with the rich biopsychosocial data available in MIDUS, including wide-ranging assessments of stress exposures across multiple waves, thereby providing indicators of cumulative adversity. MIDUS is also known for its comprehensive assessments of psychosocial and behavioral protective factors, thereby advancing research on resilience in the face of challenge. Aging on a changing historical stage is another key theme in MIDUS exemplified by a past focus on hardships of the Great Recession, and going forward, a new parallel focus on hardships of the COVID-19 pandemic. In terms of scientific engagement, MIDUS is the most frequently downloaded study at the National Archive of Computerized Data on Aging (NACDA). Widespread usage from the scientific community (26,000+ public users) has culminated in 1,617 publications covering 38 substantive domains. Underscoring the momentum behind MIDUS, more than half of these products are journal articles published during the current funding cycle (2016-present).