Center for the Assessment of Tobacco Regulations (CAsToR) TCORS 3.0

居中摘要 烟草法规评估中心(Castor)的综合主题是提供 FDA烟草对行为和公共健康影响的循证和专家信息建模 规则或其他监管行动，将影响分析、行为和健康影响作为科学的重点 域。为了评估烟草使用和管制对公众健康的影响，必须收集信息。 来自不同来源对烟草使用行为、健康风险以及法规对使用模式的影响。 然后，必须以系统和客观的方式综合和处理这些信息，以帮助制定政策 制定者衡量这样的规定将对人口水平产生的影响，并帮助他们 决策过程。烟草使用模式和相关健康结果的模拟建模可以帮助 作为帮助FDA评估和预测人群水平的益处和危害的关键工具 与新的和现有的烟草产品有关的监管政策。当有效地应用时，建模还 成为组织和综合不同信息源并找出其中差距的一种方式 信息，特别是在不同社会经济人口的烟草使用模式不同的情况下。我们的中心 将有四个基于对美国当前和历史烟草使用模式的详细分析的项目 使用已建立的烟草模拟模型，以不同的方法提供一系列不同的见解。 项目1(影响分析、健康影响和行为)的总体目标是进行比较 FDA监管行动和新型烟草产品对烟草使用和长期影响的模拟 健康结果。项目2(成瘾、行为、影响分析和健康影响)将模拟 青少年和年轻人中的尼古丁成瘾及其潜在的未来后果。项目3(影响 分析和行为)将开发工具来评估香料限制对吸烟和蒸发的影响 美国总人口以及城市和农村人口。项目4(行为、健康影响和影响 分析)将为弱势人群开发模型，并评估烟草使用和法规的影响 按种族/民族、教育程度和他们的交集。四个核心将为中心提供服务：行政核心 (Ac)协调各项目和核心的工作；职业促进核心(CEC)提供培训 向初级调查人员介绍烟草管制科学和模拟建模的能力和局限性； 数据分析和建模(DAM)核心，用于分析和提供每个模型和 发展传播模型参数和模拟结果的基础设施；以及政策和 传播(PAD)核心，以生成关键政策和健康影响的估计，通过 系统评价、荟萃分析和专家小组。

CENTER Abstract The integrative theme for the Center for the Assessment of Tobacco Regulations (CAsToR) is to provide evidence-based and expert-informed modeling of the behavioral and public health impacts of FDA tobacco rules or other regulatory actions, focusing on Impact Analysis, Behavior and Health Effects as Scientific Domains. To evaluate the public health impacts of tobacco use and regulation, information must be gathered from different sources on tobacco use behaviors, health risks and the impact of regulations on use patterns. This information must then be synthetized and processed in a systematic and objective manner, helping policy makers gauge the impact that such regulations would have at the population level and aiding them in their decision-making process. Simulation modeling of tobacco use patterns and related health outcomes can serve as a key tool to assist FDA in evaluating and predicting population-level benefits and harms resulting from regulatory policies pertaining to new and existing tobacco products. When effectively applied, modeling also becomes a way of organizing and synthesizing different sources of information and identifying gaps in that information, especially where tobacco use patterns vary for different socio-economic populations. Our Center will have four projects based on the detailed analyses of current and historical tobacco use patterns in the US using established tobacco simulation models, with different approaches to provide a range of diverse insights. The overarching aim of Project 1 (Impact Analysis, Health Effects, and Behavior) is to conduct comparative modeling of the impact of FDA regulatory actions and novel tobacco products on tobacco use and long-term health outcomes. Project 2 (Addiction, Behavior, Impact Analysis, and Health Effects) will model the process of nicotine addiction among youths and young adults and its potential future consequences. Project 3 (Impact Analysis and Behavior) will develop tools to assess the impact of flavor restrictions on smoking and vaping for the overall US population and for urban and rural populations. Project 4 (Behavior, Health Effects, and Impact Analysis) will develop models for vulnerable populations and assess the impact of tobacco use and regulations by race/ethnicity, education, and their intersection. Four cores will serve the Center: the Administrative Core (AC) to coordinate the work of the projects and cores; the Career Enhancement Core (CEC) to provide training to junior investigators on the capabilities and limitations of tobacco regulatory science and simulation modeling; the Data Analysis and Modeling (DAM) Core to analyze and provide the data for each of the models and develop infrastructure for dissemination of model parameters and modeling results; and the Policy and Dissemination (PAD) Core to generate estimates for key policy and health effects, modeling parameters via systematic reviews, meta-analyses, and expert panels.