Acquisition of an 800 MHz NMR Spectrometer Console and Probes

申请资金用于购买布鲁克Biospin NMR AVANCE NEO 800 MHz控制台， 相关组件，包括BMPC-2磁体控制系统、CryoPlatform/5、MASIII 气动控制单元，TCI-H&F三重共振冷冻探头，MAS三伽马1.9 mm固态 探针和MAS 3.2 mm固态CryoProbe，安装在现有的Bruker Biospin 800 MHz 核磁共振磁铁系统。安装了当前的NMR AVANCE I控制台和TCI CryoProbe/1 2003年和2004年，Bruker Biospin宣布已于2018年达到“服务终止”（EOS） 2019年，分别。所要求的仪器提供了增强的灵敏度和能力 现代NMR实验，包括温度锁定，非均匀采样，复杂的 波形生成，魔角旋转（MAS）固态NMR光谱，和先进的 用于溶液和固态MAS应用的低温探头设计。请求的 仪器对于纽约结构生物学中心至关重要 （NYSBC），一个由纽约州的九个研究机构组成的联盟，以支持 美国国立卫生研究院资助的光谱仪的主要和次要用户的研究。进行的研究 800 MHz NMR光谱仪的范围从结构/功能的基础研究， 生物分子，阐明发病机制，发现新的先导化合物 到制药应用。所要求的仪器将大大提高能力 800兆赫核磁共振波谱仪进行这项研究。

Funding is requested to obtain a Bruker Biospin NMR AVANCE NEO 800 MHz Console and associated components, including BMPC-2 magnet control system, CryoPlatform/5, MASIII pneumatic control unit, TCI-H&F triple-resonance CryoProbe, MAS tri-gamma 1.9 mm solid-state probe, and MAS 3.2 mm solid-state CryoProbe, to be installed on an existing Bruker Biospin 800 MHz NMR magnet system. The present NMR AVANCE I console and TCI CryoProbe/1 were installed 2003 and 2004 and were declared by Bruker Biospin to have reached “End of Service” (EOS) in 2018 and 2019, respectively. The requested instrumentation provides enhanced sensitivity and capabilities for modern NMR experiments, including temperature-locking, non-uniform sampling, complex waveform generation, magic-angle spinning (MAS) solid-state NMR spectroscopy, and advanced cryogenic probe design for both solution and solid-state MAS applications. The requested instrumentation is essential to the over-riding purpose of the New York Structural Biology Center (NYSBC), a consortium of nine research institutions in New York State, to support the specific aims of the NIH-funded research of the major and minor users of the spectrometer. Research conducted on the 800 MHz NMR Spectrometer ranges from fundamental studies of structure/function of biomolecules, to elucidation of mechanisms of pathogenesis, to discovery of novel lead compounds to pharmaceutical applications. The requested instrumentation will dramatically enhance the capacity of the 800 MHz NMR spectrometer to conduct this research.