STORAGE OF NUMOM2B SPECIMENS FOR THE PREGNANCY AND PERINATOLOGY BRANCH OF NICHD

尤尼斯·肯尼迪·施莱弗国家儿童健康和人类发展研究所(NICHD)建立了未分娩妊娠结局研究：监测准妈妈(NuMoM2B)，以研究当前怀孕将导致其第一次分娩的妇女(未分娩)。在美国，未产妇约占孕妇总数的40%。由于没有以往妊娠结局的信息来指导风险分配或减轻干预措施，因此未足月产妇的不良妊娠结局尤其不可预测。不良妊娠结局的潜在机制，如早产、先兆子痫和胎儿生长受限是相互关联的，因此将作为本研究的一部分进行评估。 NuMoM2B研究是一项对10,000多名未分娩妇女从怀孕前三个月到分娩期间进行的前瞻性观察研究，以了解从怀孕前三个月开始不良妊娠结局的机制和病因。这项研究在八个临床地点进行，包括哥伦比亚大学、印第安纳大学、凯斯韦斯特大学和俄亥俄州立大学、加州大学欧文分校、宾夕法尼亚大学、匹兹堡大学、西北大学和犹他大学。数据协调中心是三角研究院(RTI)国际和网络。所有10 000名参与者的注册工作已于2013年9月完成，最后一名参与者于2014年5月提交。所有研究参与者都接受了一系列评估，包括人口学、营养、家族史、孕妇人体测量、病史、心理社会因素评估、胎儿生长的超声测量、胎盘功能(子宫动脉多普勒)和生物样品采集(孕妇血清、血浆、尿液、宫颈/Vag、分娩时胎盘)。

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) established the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) to study women for whom the current pregnancy will lead to their first delivery (nulliparas). Nulliparas comprise about 40% of pregnant women in the United States. Because no information is available from previous pregnancy outcomes to guide assignment of risk or mitigating interventions, adverse pregnancy outcomes in nulliparas are especially unpredictable. The underlying mechanisms of adverse pregnancy outcomes such as preterm birth, preeclampsia, and fetal growth restriction are interrelated, and therefore will be evaluated as part of this study. The NuMoM2b study was a prospective observational study of over 10,000 nulliparous women followed from the first trimester through delivery to understand the mechanism and etiology of adverse pregnancy outcomes starting in the first trimester. It was conducted at eight clinical sites including Columbia University, Indiana University, Case Western and Ohio State Universities, University of California at Irvine , University of Pennsylvania, University of Pittsburgh, Northwestern University, and University of Utah. The data coordinating center was Research Triangle Institute (RTI) International and the Network. Enrollment of all I0,000 participants was completed in September of 2013 and the last participant delivered May 2014. All study participants underwent serial evaluations including demographics, nutrition, family history , maternal anthropometric measurements, medical history, assessments of psychosocial factors, ultrasound measures of fetal growth, placental function (uterine artery Doppler) and biospecimen collection (maternal serum, plasma, urine, cerv ical/vag in al samples, placenta at delivery).