NEI Center Core Grant for Vision Research

总结 整体 视觉研究中心核心补助金的总体目的是提供核心服务和资源 提高和加速视觉研究社区的生产力和影响力在大学 加州，圣地亚哥。具体来说，视觉研究中心核心补助金将利用优秀的 国家眼科研究所的基础科学和临床研究专业知识，通过提供 重要的资源和服务分为以下五个不同的核心。 1. Vision Biostatistics Core为视觉研究社区提供专门的统计专业知识， 加州大学圣地亚哥分校有几个常见的分析主题和统计问题可以有效地解决 并通过拥有一名熟悉眼部研究的专业生物统计学家来分析与视觉相关的数据 并确保结果的严谨性和透明度。 2.动物结构和功能中心将提供共享的仪器和技术人员协助 在动物的眼部结构成像和功能成像中。 3.计算眼科学和生物医学信息学核心提供i）专用的高- 高性能CPU和GPU计算资源ii）3名计算机程序员，iii）机构软件 许可证，iv）电子健康记录数据提取服务，v）基于云的数据管理 基础设施，以及vi）安全的文件共享和备份服务，以支持UCSD的蜂窝，动物和 人类视觉研究。 4.组织学、组织处理和高含量显微镜核心可快速表征 眼组织的组织学、免疫组织化学和高含量显微镜检查用于药物筛选 和组织学标本成像的支持仪器和技术人员谁是熟悉的眼睛 正确处理眼组织所需的解剖学和技术。 5.新的病毒生产和CRISPR工程核心提供集中的专用空间， 腺相关病毒（AAV）生产、分离和滴定的设备和人员， 慢病毒（LV）载体和辅助非病毒CRISPR基因编辑。 这些核心将提高UCSD视觉科学家的效率，生产力和影响力， 个别调查人员无法获得或不易获得的核心服务。核心补助金 基础设施和资源还可以利用每个参与研究者的专业知识， 多学科合作，为整个UCSD视觉研究社区的利益。

SUMMARY Overall The overall purpose of the Center Core Grant for Vision Research is to provide core services and resources to enhance and accelerate the productivity and impact of the vision research community at the University of California, San Diego. Specifically, the Center Core Grant for Vision Research will leverage the outstanding basic science and clinical research expertise of National Eye Institute funded investigators by providing important resources and services organized into the following five distinct cores. 1. The Vision Biostatistics Core provides dedicated statistical expertise for the vision research community at UCSD. There are several common analysis themes and statistical issues that can be addressed effectively and efficiently by having a dedicated biostatistician familiar with eye research to analyze vision-related data and to ensure rigor and transparency of the results. 2. The Animal Structure and Function Core will provide shared instrumentation and a technician to assist with ocular structural imaging and functional imaging in animals. 3. The Computational Ophthalmology and Biomedical Informatics Core provides i) dedicated high- performance CPU and GPU computing resources ii) 3 computer programmers, iii) institutional software licenses, iv) electronic health record data extraction services, v) cloud-based data management infrastructure, and vi) secure file sharing and backup services to support UCSD’s cellular, animal and human vision research studies. 4. The Histology, Tissue Processing and High Content Microscopy Core provides rapid characterization of eye tissue with respect to histology, immunohistochemistry and high content microscopy for drug screening and histologic specimen imaging by supporting instrumentation and a technician who is familiar with ocular anatomy and techniques required to properly process ocular tissues. 5. The new Viral Production and CRISPR Engineering Core provides centralized dedicated space, equipment and personnel for the production, isolation and titering of adeno-associated virus (AAV) and lentivirus (LV) vectors and assistance with non-viral CRISPR gene editing. These cores will improve the efficiency and productivity and impact of UCSD vision scientists by providing core services that are unavailable or not easily accessible to individual investigators. The core grant infrastructure and resources also leverage the expertise of each participating investigator to enhance multidisciplinary collaboration for the benefit of the entire UCSD vision research community.