Autonomic Nervous System And Energy Metabolism In Humans

本项目的主要目的是研究自主神经系统在能量代谢调节中的作用及其在肥胖和2型糖尿病病理生理中的可能作用。我们使用微神经造影测量肌肉交感神经活动（MSNA）和血浆/尿液儿茶酚胺测量全球交感神经系统（SNS）活动。我们使用空腹和餐后胰多肽、瞳孔测量、心率/血压测试和胃排空率来评估副交感神经系统（PNS）的活动。在过去的一年里，我们完成了一项合作研究，以评估皮马人和高加索人在11- β - hsd活性（一种皮质醇敏感性的组织特异性调节剂）方面可能存在的差异（目前正在分析数据）；b)继续研究PNS在Pimas和高加索人胰岛素分泌功能中的作用（正在进行中）；c)继续研究皮马人和白种人对标准膳食的社交网络反应（正在进行中）

The main aim of this project is to study the role of the autonomic nervous system in the regulation of energy metabolism and its possible contribution to the pathophysiology of obesity and type 2 diabetes. We use microneurography to measure muscle sympathetic nerve activity (MSNA) and plasma/urine catecholamines to measure global sympathetic nervous system (SNS) activity. We use fasting and post-prandial pancreatic polypeptide, pupillometry, heart rate/blood pressure tests, and gastric emptying rate to assess parasympathetic nervous system (PNS) activity. In the past year we have: a) completed a collaborative study to assess possible differences in 11-beta-HSD activity, a tissue specific modulator of cortisol sensitivity, in Pimas and Caucasians (data being currently analyzed); b) continued a study on the role of PNS in insulin secretory function in Pimas and Caucasians (ongoing); c) continued a study on the SNS response to a standard meal in Pimas and Caucasians (ongoing)