A New Herbal Growth Factor for Periodontal Regeneration

描述：牙周炎是牙齿移动和丧失的主要原因。20%的美国成年人患有严重的牙周炎，导致牙齿的支撑结构遭到破坏，包括牙槽骨。牙周手术可以减缓疾病的进展，但费用昂贵，受到禁忌症的限制，经常需要反复治疗，而且不会再生丢失的牙周结构。为此，采用了几种再生模式。特别令人感兴趣的是生物制剂的使用，如骨形态发生蛋白和血管刺激生长因子(例如，碱性成纤维生长因子)。不幸的是，这些刺激物经过蛋白质分解，不能轻易地维持在治疗部位的治疗水平。在这里，我们建议测试SBD.4的再生能力-一种从药用植物中分离出来的新型稳定的非蛋白质分子，强烈刺激血管生成、成纤维细胞和成骨细胞的生长以及胶原的合成-牙周再生所需的活动。我们将进一步对这种新化合物进行表征，并在小鼠颅骨再生模型中对其进行测试，该模型特别适用于潜在的抗牙周炎疗法的中试测试。根据微电脑断层扫描和组织形态计量学的测量，目标终点将是骨再生增加至少30%。如果成功，该项目将产生一种治疗牙周病的临床前候选药物。

DESCRIPTION: Periodontitis is the major cause of teeth motility and loss. Twenty percent of adult Americans suffer severe periodontitis, resulting in destruction of the supporting structures of teeth, including the alveolar bone. Periodontal surgery can slow the progression of the disease, but is costly, limited by contraindications, often requires repeated treatment and does not regenerate lost periodontal structures. To that end, several regenerative modalities have been employed. Of particular interest has been the use of biologicals, such as bone morphogenetic proteins and angio-stimulatory growth factors (e.g., bFGF). Unfortunately, these stimulators undergo proteolysis, and cannot be readily maintained in treatment sites at therapeutic levels. Here, we propose to test the regenerative capabilities of SBD.4-a novel stable, non-proteinaceous molecule isolated from a medicinal plant, strongly stimulating angiogenesis, fibroblast and osteoblast growth and collagen synthesis-the activities needed for periodontal regeneration. We will further characterize this new compound and will test it in the murine calvarial bone regeneration model, which is particularly suitable for pilot testing of potential anti-periodontitis therapies. Targeted endpoint will be increased bone regeneration by at least 30% as measured by micro-computerized tomography and histomorphometry. If successful, this project will result in a preclinical drug candidate for treatment of periodontal disease.