Peptide-based Star Polymers for Improved Biointeraction and Targeted Anticancer Therapies

该项目的目的是开发基于肽的星形聚合物纳米载体，将适体靶向技术和血浆液体生物相互作用研究相结合，用于靶向药物递送到癌症干细胞。这项研究的重要意义在于，它开创了一种药物输送系统的发展，通过了解聚合物-等离子体相互作用，最大限度地减少血浆调理作用，从而通过结合靶向适体和触发药物释放，增加肿瘤特异性和细胞内化。该项目将采用合理的设计，先进的大分子工程和跨学科合作，以产生用于药物输送的下一代聚合物疗法。

The aim of this project is to develop peptide-based star polymer nanocarriers for targeted drug delivery to cancer stem cells which integrate aptamer targeting technology and biointeraction studies with blood plasma fluid. The significance of this research is it pioneers the development of a drug delivery system that minimises plasma opsonization through understanding polymer-plasma interactions, which in turn increases tumour specificity and cell internalisation through incorporation of targeting aptamers and triggered drug release. This project will use rational design, advanced macromolecular engineering and an interdisciplinary collaboration to generate next-generation polymer therapeutics for drug delivery.