Renovation of Building 4 to Provide BSL-2 Housing for Infectious Disease Research

描述（由申请人提供）：对传染病的研究已经并将继续是西南国家灵长类动物研究中心（SNPRC）的公共卫生支持的研究计划的重要组成部分。NPRC计划为核心教师和需要非人灵长类动物模型的更广泛研究社区的成员提供资源和专业知识。传染病研究的最新趋势，包括需要恒河猴模型的艾滋病相关研究和生物防御/新出现的感染研究，导致对需要严格控制的服务项目的需求增加。在SNPRC，缺乏BSL-2空间可用于根据研究协议容纳非人灵长类动物，这导致了延迟，阻碍了我们进行传染病，包括艾滋病相关研究的能力。 该申请寻求资金，以改善SNPRC的基础设施，翻新现有的3，280总平方英尺的建筑物，为非人灵长类动物提供新的BSL-2收容所。翻修后的建筑将包含三个动物饲养室，提供总计1，593平方英尺的饲养空间，一个185平方英尺的手术室和相关的支持空间，并将弥补目前空间利用和交通流量的不足。现有的供暖、通风和空调系统提供循环空气，将被一个提供100%新鲜空气的新系统取代。其他建筑物系统，包括配电设备、电线和管道，都是1966年最初建造的，将在翻修期间更换和升级，以提供可靠的服务和足够的能力。

DESCRIPTION (provided by applicant): Research on infectious diseases has been and will continue to be an important component of the PHS-supported research program at the Southwest National Primate Research Center (SNPRC). The NPRC program makes available resources and expertise to core faculty and to members of the broader research community who require nonhuman primate models. Recent trends in infectious disease research, including AIDS-related research requiring rhesus macaque models and biodefense/emerging infections research, have resulted in an increased need to service projects requiring stringent containment. At the SNPRC, the lack of BSL-2 space available for housing nonhuman primates on research protocols has resulted in delays that impede our ability to conduct infectious disease, including AIDS-related, research. This application seeks funds to improve the infrastructure at SNPRC by renovation of an existing 3,280 gross square foot building to provide new BSL-2 containment for nonhuman primates. The renovated building will contain three animal housing rooms providing a total of 1,593 square feet of housing space, a 185 square foot procedure room, and associated support spaces, and will remediate current deficiencies of space utilization and traffic movement. The existing heating, ventilation and air conditioning system, which provides recirculated air, will be replaced with a new system providing 100% fresh air. Other building systems, including electrical distribution equipment and wiring and plumbing, both of which date from original construction in 1966, will be replaced and upgraded during the renovation to provide reliable service and adequate capacity.