Institute for Biomedical and Health Disparities Research

描述（由申请人提供）：本提案的目的是在RCMI之前的支持基础上，在全国最大的单一校园HBCU（历史上的黑人学院和大学）TSU建立一个生物医学和健康差异研究所。该研究所将继续作为托国立主要的研究基础设施建设实体，并将帮助托国立实现其战略研究愿景，同时满足国家解决和缓解涉及心血管疾病，糖尿病，艾滋病和许多其他疾病的健康差距的需要。该研究所的研究目标是在生物医学和健康差异研究的一个或多个领域成为领导者并获得全国突出地位。本应用程序中提出的基础设施将为TSU的研究人员提供他们需要的研究资源，以进行重大的基础科学发现，这些发现可能导致识别与疾病过程有关的新基因或蛋白质。这些发现可能会增加这些研究人员开发新的药物和/或系统来诊断、治疗、预防或治愈疾病的潜力。托国立未来十年的战略研究愿景包括：在培养多样化、高度竞争、训练有素的生物医学研究骨干方面发挥领导作用；为开展生物医学和行为研究提供最先进的研究设施；在生物医学和制药科学领域建立新的研究生学位课程；新建15.7万平方英尺。耗资4000万美元的科学大楼；在托大和其他地方开展高效的研究合作；创建多个教授和主席职位；并在环境毒理学、生物医学或健康差异研究的一个或多个领域获得国家认可。拟议的研究所考虑到科学研究技术的进步，因此要求得到必要的大量支持，以便将托国立大学快速推进到这一水平。为了实现上述目标，并加快发现和研究转化为患者，我们建议创建生物标志物和生物传感器技术的核心设施；计算研究;分子生物学与组织工程；蛋白质组学和功能基因组学。此外，我们将招募两名新的既定调查员；继续发展目前RCMI项目聘用的五名现有教师；指导学生发展计划；将同行评议出版物的平均年数量从15篇增加到20篇；将平均提交拨款申请的数目由28宗增加至50宗；并将NIH和其他资助机构的竞争性校外生物医学研究奖项的年度数量从16个增加到32个。NCRR对拟议中的研究所的持续支持将有助于利用其投资，提供最先进的基础设施，使TSU的研究人员能够与其他机构的科学家竞争，以获得与美国公共卫生服务使命相关的生物医学和/或行为研究的支持。通过在TSU投资这项研究基础设施建设工作，NCRR将在其努力扩大健康科学研究能力和促进国家生物医学研究能力方面拥有一个强有力的合作伙伴。

DESCRIPTION (provided by applicant): The purpose of this proposal is to build on previous RCMI support and develop an Institute for Biomedical and Health Disparities Research at the largest single campus HBCU (Historically Black Colleges and Universities) in the nation, TSU. The Institute will continue to serve as TSU's premier research infrastructure building entity and will help TSU achieve its strategic research vision, while meeting the national need to address and ease health disparities involving cardiovascular illnesses, diabetes, AIDS, and many other diseases. The Institute's goals for research are to become a leader and gain national prominence in one or more areas of biomedical and health disparities research. The infrastructure proposed in this application will provide TSU researchers with the research resources they need to make major basic science discoveries that may lead to the identification of novel genes or proteins involved in a disease process. These discoveries may increase the potential of these researchers to develop novel drugs and/or systems to diagnose, treat, prevent, or cure a disease. TSU's strategic research vision for the next decade includes leadership in providing a diverse, highly competitive, and well trained cadre of biomedical researchers; providing state-of-the-art research facilities for the conduct of biomedical and behavioral research; creating new graduate degree programs in the biomedical and pharmaceutical sciences; constructing a new 157,000 sq. ft, $40 million Science Building; developing highly productive research collaborations at TSU and elsewhere; creating multiple endowed professorships and Chairs; and achieving national recognition in one or more areas of environmental toxicology, biomedical, or health disparities research. The proposed Institute takes into account the advances in scientific research technology, and as such is requesting substantial support that will be needed to fast forward TSU to this level. To achieve the aforementioned goals and to accelerate discovery and translation of research to patients, we propose to create core facilities in biomarker and biosensor technology; computational research; molecular biology and tissue engineering; and proteomics and functional genomics. Further, we will recruit two new established investigators; continue to develop the five existing faculty hired under the current RCMI program; conduct a mentored student development program; increase the average annual number of peer-reviewed publications from 15 to 20; increase the average number of grant application submissions from 28 to 50; and double the annual number of competitive extramural biomedical research awards from the NIH and other granting agencies from 16 to 32. NCRR's continued support of the proposed Institute will help to leverage its investment by providing state-of-the-art infrastructure that will enable TSU investigators to compete with scientists at other institutions to obtain support for the conduct of biomedical and/or behavioral research relevant to the mission of the U.S. Public Health Service. By investing in this research infrastructure building effort at TSU, the NCRR will have a strong partner in its effort to expand the capability for research in the health sciences and contribute to national biomedical research capability.