Regulatory Circuits and Virulence in Candida albicans
Regulatory Circuits and Virulence in Candida albicans
批准号:
7568750
负责人:
ALEXANDER D JOHNSON
金额:
$63.83万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-03-01 至 2011-02-28
关键词:
AreaBindingCandidaCandida albicansCellsChromansCollaborationsEnvironmentFilamentGastrointestinal tract structureGene TargetingGenesGenetic ScreeningGenomeGoalsGrowthHumanImmunocompromised HostImmunoprecipitationInfectionKnock-outLaboratoriesMammalsMolecularMusOrganismPartner in relationshipPathogenesisPatternProceduresPropertyRNA SplicingRoleSaccharomyces cerevisiaeSchemeSystemic infectionVirulenceYeastsbasecell typedesignfitnessmouse modelpathogenprograms
中文摘要
白色念珠菌是哺乳动物消化道中的一种寄生生物。也是
最常见的人类真菌病原体,引起粘膜和全身感染,特别是在
免疫力低下的人该提案涵盖念珠菌六个不同方面的研究,其中五个
与发病机制有关(The第六章还没有研究过)。这些领域是(1)
芽生孢子到丝状体形态的可逆转变,(2)菌丝顶端细胞的特化,(3)
白色不透明转换,(4)交配,(5)“毒力”基因的鉴定,(6)
调节RNA剪接的毒性。
英文摘要
The yeast Candida albicans is found as a commensal organism in the digestive tract of mammals. It is also
the most common human fungal pathogen, causing both mucosal and systemic'infections, particularlyin
immunocompromised people. This proposal covers studies of six different aspects of Candida five of which
have been implicated in aspects of pathogenesis. (The sixth has not yet been studied.) These areas are (1)
the reversible blastospore to filament morophologica transitions, (2) specialization of hyphal tip cells, (3)
white-opaque switching, (4) mating, (5) the identification of 'virulence' genes and, (6) the possible role of
regulated RNA splicing in virulence.
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会议论文
Regulatory Circuits and Virulence in Candida albicans
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负责人:ALEXANDER D JOHNSON
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依托单位:
Regulatory Circuits and Virulence in Candida albicans
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批准号:8589572
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批准号:8232963
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依托单位:
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