Mass Spec Resource

NERCE：质量谱资源-Stephen Calderwood，M.D. LTQ XL是一种快速扫描串联质谱仪，能够对几种多肽进行测序 每秒，允许快速表征和量化(使用同位素标记)来自 微生物。该仪器还具有几种中间扫描模式，允许进行中性点损耗分析 磷酸基团，以及用于电荷状态评估的一些中等全扫描分辨率模式。这个 仪器具有比LTQ-FT更高的占空比，并且对较低水平的多肽具有更高的灵敏度。 对于致力于NIAID优先病原体的新英格兰调查人员来说，优先使用这种仪器， 因此，蛋白质和多肽的快速鉴定将促进相关的基础和应用科学 NERCE的任务，如鉴定作为潜在靶点的病原体蛋白 抗菌药物的开发。这一资源通过电子邮件向NERCE调查人员公布 网站，并在适当的时候直接沟通。

NERCE: Mass Spec Resource - Stephen Calderwood, M.D. The LTQ XL is a fast scanning tandem mass spectrometer, capable of sequencing several peptides every second, allowing rapid characterization and quantification (using isotope labels) of proteins from microbes. The instrument also has several intermediate scan modes, allowing for neutral loss analysis of phosphate groups, as well as some medium full scan resolution modes for charge state assessment. The instrument has a higher duty cycle than the LTQ-FT, and a higher sensitivity for lower level peptides. Use of this instrument is prioritized for New England investigators working on NIAID Priority Pathogens, for which rapid identification of proteins and peptides will facilitate basic and applied science of relevant to the missions of NERCE, such as the identification of pathogen proteins that are potential targets for antimicrobial development. This resource is publicized to NERCE investigators via e-mail, the NERCE Website, and direct communication when appropriate.