Signal Processing And Instrumentation Section

信号处理和仪器科(SPIS)的研究和开发活动是与NIH研究所的科学家共同努力的，通常导致开发独特的、专门的生物医学仪器。其他项目涉及系统模拟和信号分析所需的信号和视频处理算法开发。SPIS的能力和成就使该集团成为NIH这类工程研究和技术开发的焦点。技术开发和项目实例包括： *cDNA和蛋白质微阵列 *组织芯片(TMA) *激光捕获显微切割(LCM) *表达微切割(XMD) *染色体显微切割 *微流体学、微制造和微分析 *单分子、DNA和染色质纤维的机械和操纵 *高速扫描光谱分析 *原子力显微镜(AFM) *电子顺磁共振(EPR)成像 *磁共振成像(MRI)和功能磁共振成像(FMRI)方法和设备 *磁共振弹性成像(MRE)成像 *超声成像 *正电子发射断层扫描(PET)成像 *伽马相机成像 *荧光成像 *双光子激发荧光显微镜(TPEFM) *语音采集和实时自适应处理 *生物力学实时步态分析 *用于研究小鼠疼痛的神经特异性伤害性测试 *非人灵长类母婴监测 *自动鼠标活动监控系统(MAMS)

The research and development activities of the Signal Processing and Instrumentation Section (SPIS) are collaborative efforts with NIH Institute scientists, and often result in the development of unique, specialized biomedical instruments. Other projects involve signal and video processing algorithm development required for system simulation and signal analysis. SPIS capabilities and accomplishments have established the group as the focal point for this type of engineering research and technology development at the NIH. Example technology developments and projects include: * cDNA and protein microarray * tissue microarray (TMA) * laser capture microdissection (LCM) * expression microdissection (xMD) * chromosome microdissection * microfluidics, microfabrication, and microanalysis * single molecule, DNA, and chromatin fiber mechanics and manipulation * high-speed scanning spectrometry * atomic force microscopy (AFM) * electron paramagnetic resonance (EPR) imaging * magnetic resonance imaging (MRI) and functional MRI (fMRI) methodologies and devices * magnetic resonance elastography (MRE) imaging * ultrasound imaging * positron emission tomography (PET) imaging * gamma camera imaging * fluorescence imaging * two-photon excitation fluorescence microscopy (TPEFM) * speech acquisition and real-time adaptive processing * biomechanics real-time gait analysis * neuro-specific nociceptive assay for mouse pain studies * nonhuman primate maternal-fetal monitoring * automated mouse activity monitoring system (MAMS)