NEIBank: Est Analysis And Bioinformatics For Ocular Genomics

许多人类的眼睛(以及耳朵)组织和重要的动物模型的组织现在已经被分析。此外，NEIBank的合作还增加了其他感官组织、耳朵和味蕾的数据。最近增加的眼睛包括人视神经、人翼状胬肉、恒河猴和奶牛晶状体以及斑马鱼角膜。该DNA资源已被用来创建包含13,000个非冗余人眼表达序列和6500个来自小鼠眼睛的序列的基因芯片。这些正被用于分析人类细胞反应和转基因小鼠模型。来自NEIBank兔眼图书馆的数据已经被用于与佛罗里达大学的研究小组合作创建第一个用于兔眼研究的DNA微阵列。 眼睛研究信息学工具的一个强大补充是EyeBrowse，这是与CIT合作开发的专门用于眼睛表达基因的基因组浏览器。Http://eyebrowse.cit.nih.gov/genome/；是已知人类眼病基因的数据库，也是比较不同组织和物种表达模式的新工具。此外，NEIBank现在将来自EyeSAGE项目(Duke U)的数据与用于人眼来源的SAGE数据的定制基因组浏览器轨道相结合。另一项新增内容是人类眼病基因数据库，目前正在进行更新和注释。

Many human eye (and also ear) tissues and those of important animal models have now been analyzed. In addition NEIBank collaborations have added data on other sensory tissues, ear and taste bud. Recent eye additions include human optic nerve, human pterygium, rhesus monkey and cow lens and zebrafish cornea,. This DNA resource has been used to create cDNA microarrays with 13,000 non-redundant human eye expressed sequences and 6500 sequences from mouse eye. These are being used in analysis of human cellular responses and genetically modified mouse models. Data from NEIBank rabbit eye libraries have been used to create the first DNA microarray for rabbit eye research in collaboration with groups from the University of Florida. A powerful addition to the informatics tools for eye research is EyeBrowse, a dedicated genome browser for eye-expressed genes, produced in collaboration with CIT. http://eyebrowse.cit.nih.gov/genome/; a database for known human eye disease genes and a new tool to compare expression patterns of different tissues and species. In addition, NEIBank now incorporates data from the EyeSAGE project (Duke U) with a custom genome browser track for human eye-derived SAGE data. Another addition is a database of human eye disease genes which is currently undergoing update and annotation.