INSULIN RESISTANCE, AGING AND THEIR RELATION TO MUSCLE AND LIVER LIPID CONTENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 与年龄相关的胰岛素抵抗的发展在文献中是有充分记录的发现。此外，胰岛素抵抗的程度与肌肉和肝脏中细胞内脂肪堆积的程度之间存在关系。因此，我们建议在表面健康的个体中确定胰岛素抵抗和衰老之间的关系，作为肌肉和肝脏脂肪含量的函数。为此，我们将研究一组年轻人(18至35岁)和一组老年人(65岁以上)。胰岛素抵抗的程度将根据涉及口服葡萄糖耐量测试的程序来确定，而肌肉和肝脏的脂肪含量将使用质子磁共振波谱来确定。我们还计划研究一组患有2型糖尿病的老年个体，他们将接受与健康个体相同的测试程序。从后一组收集的数据将允许检验这一假设，即在衰老和2型糖尿病之间存在与肌肉和肝脏脂肪含量相关的共同潜在因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The development of an age-related insulin resistance is a well-documented finding in the literature. Further, there is a relationship between the degree of insulin resistance and the extent of intracellular lipid accumulation in the muscle and liver. We, therefore, propose to determine the relationship between insulin resistance and aging as a function of muscle and liver lipid contents in apparently healthy individuals. For this purpose we will study a group of young (18 to 35 years of age) and a group of old (over 65 years of age) individuals. The extent of insulin resistance will be determined on the basis of procedures involving the oral glucose tolerance test, while muscle and liver lipid contents will be determined using proton magnetic resonance spectroscopy. We also plan to study a group of elderly individuals with type 2 diabetes mellitus who will undergo the same testing procedures as the healthy individuals. Data collected from the latter group will allow testing the hypothesis that there are common underlying factors related to muscle and liver lipid contents between aging and type 2 diabetes mellitus.