ASSESSING ENERGY NEEDS OF OVERWEIGHT AND OBESE INDIVIDUALS: A COMPARISON OF ME

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是比较使用不同方法预测和测量的静息能量消耗（REE）。 研究目的1：比较3种方法测定的超重和肥胖个体的静息能量消耗：1）预测方程（Harris Benedict方程（HBE）），2）传统间接热量测定法（Vmax 29 N）与测量的呼吸商（RQ），3）手持设备（MedGemTM）与固定RQ测定REE。 研究目的#2：评估参与者对不同REE测定方法的偏好。为了检验偏好存在显著差异的假设，我们将让参与者对1）传统间接测热法（Vmax 29 N）和测量RQ进行评级，以及2）使用吸嘴固定RQ的手持式设备（MedGemTM）进行评级，以确定偏好。 研究目的#3：比较身体成分，特别是瘦体重，与REE。 研究目的4：描述与代谢综合征相关的受试者人群以及代谢综合征不同组分与REE的相关性。当存在以下与体重相关的异常中的3个或更多个时，定义为代谢综合征：男性腰围>102 cm（40 in），女性腰围>88 cm（35 in），甘油三酯（TG）> 150 mg/dl，男性高密度脂蛋白（HDL）<40 mg/dl，女性<50 mg/dl，血压>130/85 mm Hg（收缩压和/或舒张压升高），和/或空腹血糖>110 mg/dl。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this study is to compare predicted and measured resting energy expenditure (REE) using different methods. Study Aim #1: To compare resting energy expenditure in overweight and obese individuals determined by three methods: 1) prediction equation (Harris Benedict Equation (HBE)), 2) traditional indirect calorimetry (Vmax 29N) with measured respiratory quotient (RQ), and 3) hand-held device (MedGemTM) with fixed RQ to determine REE. Study Aim #2: To assess participant preference for different methods of determining REE. In order to test the hypothesis that there is a significant difference in preference, we will have the participants rate 1) traditional indirect calorimetry (Vmax 29N) with measured RQ and 2) hand-held device (MedGemTM) with fixed RQ using a mouthpiece to determine preference. Study Aim #3: To compare body composition, specifically lean body mass, with REE. Study Aim #4: To describe the subject population relative to the metabolic syndrome and the association of different components of the metabolic syndrome with REE. The metabolic syndrome is defined when 3 or more of the following abnormalities related to weight are present: Waist circumference >102 cm (40 in) in men and >88 (35 in) in women, triglycerides (TG) > 150 mg/dl, high-density lipoprotein (HDL) <40 mg/dl in men and <50 mg/dl in women, blood pressure >130/85 mm Hg (elevation of systolic and/or diastolic blood pressure), and/or fasting glucose >110 mg/dl.