BIOMEDICAL INFORMATICS RESEARCH NETWORK: NEUROLOGICAL DISORDERS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 描述（由申请人提供）： 生物医学信息学研究网络（BIRN）是最近推出的一项倡议，旨在通过利用新兴的国家网络基础设施（高速网络，分布式高性能计算和必要的软件集成能力）的能力，促进生物医学科学的大规模合作。圣地亚哥超级计算机中心和加州大学圣地亚哥分校（UCSD）医学院的科学家们担任这个大型项目的BIRN协调中心（BIRN CC）。BIRN CC服务于开发、部署和维护关键基础设施组件的关键任务，包括通过Internet 2的高带宽连接、基于网格的安全性、文件管理和计算服务、联合数据库技术以及共享可视化和分析环境。在其初始阶段，BIRN涉及12所大学的联盟，这些大学参与了以人类神经系统疾病和相关动物模型的脑成像为中心的试验台项目。研究小组正在使用结构和功能MRI对阿尔茨海默病、抑郁症和精神分裂症进行大规模、跨机构的成像研究。其他人正在使用MRI、全脑组织学和高分辨率光学和电子显微镜研究与多发性硬化症、注意力缺陷障碍、帕金森病和脑癌研究相关的动物模型。BIRN CC为BIRN合作伙伴网站之间的互动提供了协调中心，既协调又促进了一大群才华横溢的科学家的成功合作。本提案描述了BIRN CC未来五年的延续计划。在下一阶段，BIRN CC将继续支持和加强现有的基础设施，同时促进和促进BIRN参与者之间的合作。新技术的开发和实施将继续与各种试验台项目的要求紧密结合，并将借鉴初始阶段的经验教训。与此同时，BIRN基础设施将根据新兴的网格标准继续发展，预计BIRN的寿命和未来的扩展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The Biomedical Informatics Research Network (BIRN) is a recently-launched initiative to foster large-scale collaborations in biomedical science by utilizing the capabilities of the emerging national cyberinfrastructure (high speed networks, distributed high-performance computing and the necessary software integrative capabilities). Scientists at the San Diego Supercomputer Center and the School of Medicine at the University of California San Diego (UCSD) serve as the BIRN Coordinating Center (BIRN CC) for this large project. The BIRN CC serves the critical task of developing, deploying and maintaining key infrastructure components, including high bandwidth connectivity via Internet 2, Grid-based security, file management and computational services, techniques to federate databases and shared visualization and analysis environments. In its initial phase, the BIRN involves a consortium of 12 universities participating in test bed projects centered around brain imaging of human neurological disorders and associated animal models. Groups are working on large scale, cross-institutional imaging studies on Alzheimer''s disease, depression and schizophrenia using structural and function MRI. Others are studying animal models relevant to the study of multiple sclerosis, attention deficit disorder, Parkinson''s disease and brain cancer using MRI, whole brain histology and high-resolution light and electron microscopy. The BIRN CC provides the focal point for interactions among the BIRN partner sites, both coordinating and catalyzing the successful collaboration of a large group of highly talented scientists. This proposal describes continuation plans for the BIRN CC for the next five years. In the next phase, the BIRN CC will continue to support and enhance the existing infrastructure while fostering and facilitating collaboration among the BIRN participants. Development and implementation of new technologies will continue to be tightly coupled to the requirements of the various test bed projects and will be informed by lessons learned during the initial phase. At the same time, the BIRN infrastructure will continue to evolve in accordance with emerging Grid standards, anticipating the longevity and future expansion of the BIRN.