Integrating and Disseminating Functional Genomics Data

描述(由申请人提供)：过去十年全基因组研究的爆炸性增长清楚地表明，需要一种新的范式来整合生物信息并将其传播给研究界。因此，这项建议的总体目标是设计和实施系统，使基因组数据集中包含的信息能够持续集成，至少包括基因表达、2-杂交、合成致死性和系统性缺失研究，并使综合信息最初通过酵母基因组数据库(SGD)，后来通过其他模式生物数据库，随着我们创建一个普遍适用的系统，并将其提交给通用模式生物数据库(GMOD)项目，使综合信息可供研究界访问。我们设想，数据集中的信息将通过两条一般途径获得：第一，数据集成系统将成为馆长评估有关基因功能的已知情况的指南，特别是那些鲜为人知的基因；第二，我们将继续将综合数据组织到一个可直接查询的模式中。通过提供多个信息源以及以新的和更好的方式整合和查询它们的工具，我们的目标是帮助生物学家在更全球化的背景下了解单个基因或感兴趣的途径。同样重要的是，我们希望通过了解单个基因在越来越多的不同条件下的行为来增加我们对单个基因生物学作用的了解，这些知识正在利用功能基因组学的工具进行研究。

DESCRIPTION (provided by applicant): The explosion of genome-wide research over the last decade has made clear the need for a new paradigm for the way in which biological information is integrated and disseminated to the research community. Thus, the overall goal of this proposal is to devise and implement systems that make possible continuing integration of the information contained within genomic data sets, including, at a minimum, gene expression, 2-hybrid, synthetic lethality, and systematic deletion studies, and to make the integrated information accessible to the research community, initially through the Saccharomyces Genome Database (SGD), and later through other model organism databases as we create a generally applicable system and submit it to the Generic Model Organism Database (GMOD) project. We envision that information from the data sets will become accessible through 2 general routes: first, the data integration system will be a guide to curators in assessing what is known about the function of genes, especially those genes for which little is known; second, we will organize the integrated data, on a continuing basis, into a schema that can be queried directly. By providing multiple sources of information and the tools to integrate and query them in new and better ways, we aim to help biologists progress toward seeing individual genes or pathways of interest in a more global context. Equally important, we hope to add to our knowledge of the biological roles of individual genes from knowledge of their behavior in the increasing variety of different conditions that are coming under study using the tools of functional genomics.