Kansas Mental Retardation and Developmental Disabilities Research Center (MRDDRC)

堪萨斯智障的竞争性续签需要五年的核心支持， 发展障碍研究中心(MRDDRC)。堪萨斯州MRDDRC现在已经是第39个年头了， 在产生针对原因的高度有效的行为干预方面发挥了重要的国际作用， 预防和治疗精神发育迟滞及相关的继发性疾病，并描述基本情况 了解典型和非典型发育的潜在生物学知识。自成立以来，该中心一直 支持行为和生物学研究的平衡组合。在这丰富的历史基础上，一个独特的 该中心未来的贡献将是发展生物知情的行为和 药物干预和治疗方法。堪萨斯州MRDDRC的使命是支持 与精神发育迟滞的原因和预防相关的高质量基础和应用研究 预防和补救相关的继发性疾病和相关的发育障碍。至 为了实现这一使命，堪萨斯州MRDDRC旨在实现三个目标。第一，发展和发展 支持与中心使命直接相关的跨学科基础和应用研究新举措， 将堪萨斯中心的科学家聚集在一起，并促进与 其他机构的研究人员。第二，提供经济高效、科学高效的最新技术 直接提高科学的质量和影响力的核心服务、资源和设施 中心调查人员和他们的合作者。第三，提供高效率、高成本效益的系统 计划、开发、管理、协调和传播与以下方面相关的研究活动 中间。堪萨斯州MRDDRC的研究计划围绕四个综合主题领域组织，这些领域 每一项都反映了MRDD的一个中心主题，以及我们当前 努力。这些主题是：1)语言、沟通和对智力低下的认知；2)风险， 精神发育迟滞的预防和干预；3)精神发育迟滞的神经生物学；4)细胞和 早期发展的分子生物学。协调和支持76个国家的研究活动 调查人员和75个与这些主题有关的研究项目，拟设四个核心单位：a) 沟通和管理；b)生物行为测量；c)研究设计和分析；d) 综合成像。

Core Support for five years is requested for the competitive renewal of the Kansas Mental Retardation and Developmental Disabilities Research Center (MRDDRC). The Kansas MRDDRC, now in its 39th year, has played a major international role in generating highly effective behavioral interventions aimed at the causes, prevention, and treatment of mental retardation and related secondary conditions, and in delineating basic knowledge of the underlying biology of typical and atypical development. Since its inception, the center has supported a balanced portfolio of behavioral and biological research. Building on this rich history, a unique contribution of the center in the future will be the development of biologically informed behavioral and pharmacological intervention and treatment approaches. The mission of the Kansas MRDDRC is to support high quality basic and applied research relevant to the causes and prevention of mental retardation and the prevention and remediation of associated secondary conditions and related developmental disabilities. To achieve this mission, the Kansas MRDDRC is designed to accomplish three objectives. First, to develop and support new interdisciplinary basic and applied research initiatives directly relevant to the center's mission, bringing together scientists across the Kansas Center as well as promoting collaborative ventures with researchers at other institutions. Second, to provide cost-effective, scientifically generative, state of the art core services, resources, and facilities that directly enhance the quality and impact of science produced by center investigators and their collaborators. Third, to provide highly efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. The Kansas MRDDRC's research program is organized around four integrated thematic areas that each reflects a general topic central to MRDD as well as the scientific directions and strengths of our current efforts. These themes are: 1) language, communication, and cognition of mental retardation; 2) risk, prevention, and intervention in mental retardation; 3) neurobiology of mental retardation; 4) cellular and molecular biology of early development. To coordinate and support the research activities of the 76 investigators and 75 research projects associated with these themes, four core units are proposed: a) Communication and Administration; b) Biobehavioral Measurement; c) Research Design and Analysis; d) Integrative Imaging.