ROLE OF BACTERIAL TOXINS IN ATOPIC DERMATITIS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 特应性皮炎是一般人群中慢性皮肤炎症的常见原因。 已知特应性皮炎可由细菌感染引发，并且某些称为“超抗原”的细菌蛋白质有助于皮肤疾病的严重性。 目前研究的目的是调查为什么特应性皮炎患者容易发生细菌感染，以及特应性皮炎患者皮肤上发现的最常见细菌金黄色葡萄球菌产生的超抗原如何导致特应性皮炎的皮肤炎症。 这项研究将包括从12岁以上的患者身上采集细菌培养物、血液样本和皮肤活检。 对特应性皮炎细菌感染机制的理解可能会导致这种常见皮肤病的新治疗方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Atopic dermatitis is a common cause of chronic skin inflammation in the general population. It is known that atopic dermatitis can be triggered by bacterial infection and that certain bacterial proteins called "superantigens" contribute to the severity of skin disease. The goal of the current study is to investigate why patients with atopic dermatitis are prone to bacterial infection and how superantigens produced by staphylococcus aureus, the most common bacteria found on the skin of patients with atopic dermatitis, contributes to skin inflammation in topic dermatitis. The study will involve taking bacterial cultures, blood samples and skin biopsies from patients over the age of 12 years old. An understanding of mechanisms underlying bacterial infection in atopic dermatitis is likely to lead to new treatments in this common skin disease.