EPIDEMIOLOGY OF DIABETES INTERVENTIONS AND COMPLICATIONS (EDIC)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 2006年1月，疾病控制和预防中心将该队列的后续行动延长了10年。核心协议与EDIC头12年遵循的基本协议相同。糖尿病控制和并发症试验(DCCT)以及糖尿病干预和并发症流行病学(EDIC)后续研究确定了强化糖尿病治疗对视网膜病变、肾病、神经病变和心血管疾病(CVD)的短期和长期影响。此外，他们还确定了高血糖和其他危险因素在并发症发生和进展中的作用。DCCT/EDIC以前的结果对开发已在世界范围内采用的1型糖尿病的现代治疗方法具有开创性意义。DCCT/EDIC队列遵循了一致的、有效的方法，平均16(13-20年)年，保留率为94%，代表了历史上最仔细研究的1型糖尿病患者组。目前的方案描述了DCCT/EDIC队列的进一步随访，目标为：确定最初干预措施对晚期并发症的非常长期的影响；探索印记(“代谢记忆”)现象的持久性；描述糖尿病并发症的现代临床病程，包括并发症之间的相互作用和并发症的共存；检查强化治疗与常规治疗对心血管事件的长期(ER)影响；探索微血管、神经和心血管并发症发展和进展的病理生理学机制；以及确定强化治疗的长期生活质量和经济影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In January 2006, the DCCT/EDIC entered the 10-year extension of the follow-up of the cohort. The Core protocol is the same as the basic protocol followed for the first 12 years of EDIC. The Diabetes Control and Complications Trial (DCCT) and the Epidemiology of Diabetes Interventions and Complications (EDIC) follow-up study have established the short-term and longer-term impact of intensive diabetes therapy on retinopathy, nephropathy, neuropathy, and cardiovascular disease (CVD). In addition, they have defined the roles of hyperglycemia and other risk factors on the development and progression of complications. The previous results of DCCT/EDIC have been seminal in developing the modern-day therapy of Type 1 diabetes that has been adopted worldwide. The DCCT/EDIC cohort has been followed with consistent, validated methods for a mean of 16 (13-20) years with 94% retention and represents the most carefully studied group of Type 1 diabetic patients in history. The current protocol describes further follow-up of the DCCT/EDIC cohort with the goals of: determining the very long-term effects of the original interventions on advanced complications; exploring the longevity of the imprinting ("metabolic memory") phenomenon; delineating the modern-day clinical course of diabetic complications including the interactions among complications and co-occurrence of complications; examining the long (er)-term effects of intensive vs. conventional therapy on cardiovascular events; exploring the pathophysiologic mechanisms that underlie the development and progression of microvascular, neurologic, and cardiovascular complications; and defining the long-term quality of life and economic impacts of intensive therapy.