IMPACT OF A SLEEP DEBT IN MID & OLDER AGED ADULTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 先前的研究表明，年轻人睡眠减少会导致糖耐量受损，皮质醇水平升高，瘦素水平降低，心脏交感神经活动增加。在这项研究中，这些相同的标志物将在年轻、中年和老年男性和女性睡眠干预前后进行检测。 该项目旨在确定是否： 1.睡眠限制对糖耐量、内分泌、心血管功能和神经行为有不良影响。 2.延长就寝时间(支付睡眠欠款)将逆转限制睡眠后的变化； 3.个体睡眠能力与睡眠限制对健康和神经行为功能的影响有关； 4.睡眠缺失的程度预测了第一项研究中探索的生物变化的程度； 5.慢波活动(SWA)的个体差异预测个体对睡眠限制的不良影响的易感性； 6.睡眠限制的影响存在年龄或性别相关的差异。 代谢和内分泌终点将包括葡萄糖耐量和24小时激素谱的测量。已知受睡眠剥夺、血压、心率变异性和心脏阻抗、情绪、认知功能、饥饿、饱腹感和清醒脑电影响的促炎标志物将被监测。 年龄18-25岁、35-50岁和60-75岁的三组男性和女性将经历以下研究阶段：3晚8h就寝(基线)，6晚4h就寝(限制)，7晚12h就寝(恢复)和6晚10h就寝(容量)。每个阶段之后都将进行生理和神经行为测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous work has demonstrated that sleep curtailment in young adults results in impaired glucose tolerance, elevated cortisol levels, reduced leptin levels, and increased cardiac sympathetic activity. In this study these same markers will be examined in young, middle-aged and older men and women before and after sleep interventions. This project is designed to determine whether: 1. sleep restriction has adverse effects on glucose tolerance, endocrine profiles, cardiovascular function and neurobehavioral 2. extending bedtimes (paying a sleep debt) will reverse the alterations seen after sleep restriction; 3. there is a relationship between individual sleep capacity and the impact of sleep restriction on health and neurobehavioral function; 4. the magnitude of sleep loss predicts the magnitude in the biological alterations explored in # 1; 5. individual variation in slow wave activity (SWA) predicts individual susceptibility to the adverse effects of sleep restriction; 6. there are age or gender related differences in the effects of sleep restriction. Metabolic and endocrine endpoints will include measures of glucose tolerance and 24h hormonal profiles. Pro-inflammatory markers known to be affected by sleep deprivation, blood pressure, heart rate variability and cardiac impedance, mood, cognitive function, hunger, satiety, and wake EEG will be monitored. Three groups of men and women age 18-25, 35-50 and 60-75 will undergo the following study phases; 3 nights with 8h bedtimes (baseline), 6 nights of 4h bedtimes (restriction), 7 nights of 12h bedtimes (recovery) and 6 nights of 10h bedtimes (capacity). Each phase will be followed by physiological and neurobehavioral testing.