IMPULSIVE AGGRESSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的总体目的是研究遗传和环境的影响下的人类行为特征的侵略性和冲动性在人口为基础的样本的双胞胎受试者（PennTwins：一个队列开发的PI）。 在这项研究中，攻击性和冲动性将使用自我报告（生活史和个性清单）和实验室测量的攻击性和冲动性进行检查; 5-HT的措施将包括与5-HT转运蛋白相关的措施。 在这个项目的第一阶段，双胞胎将被管理的冲动和侵略和其他相关的行为变量的各种问卷。 在II期，将在芝加哥的临床神经科学研究单位研究420对双胞胎（140对同性MZ、140对同性DZ和140对异性DZ，如果在I期检测到遗传影响的性别差异，或210对同性MZ和210对同性DZ，如果在I期未检测到遗传影响的性别差异）。 将从各种实验程序收集数据，包括攻击性（点减法攻击性范式：PSAP、泰勒攻击性范式：TAP和自我攻击性范式：SAP）和冲动性（即时记忆任务：IMT、Go-Stop任务：GST和单键冲动性范式：SKIP）的实验室模拟评估血小板5-HT转运蛋白结构（即，5-HTT结合位点的数目：Bmax），功能（即，3 H-5-HT摄取速率：Vmax）和基因型（5-HTT启动子DNA多态性），以确定β-羟色胺能功能的测量是否证明遗传性的证据，并检查遗传影响的性质，该影响对先前二十年研究中建立的5-HT和攻击性/冲动性之间的逆表型相关性有影响。 要求CRC资源的主要目的是提供辅助服务，以获取用于血小板5-HT转运蛋白结合/摄取速度的血液样本，获取用于血小板5-HT转运蛋白结合/摄取速度的血液样本，以及获取用于DNA提取的血液样本，以确认接合性状态和用于5-HT转运蛋白多态性的基因分型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this study is to examine the gentic and environmental influences underlying the human behavioral traits of aggression and impulsivity in a population-based sample of twin subjects (PennTwins: a cohort developed by the PI). In this study, both aggression and impulsivity will be examined using self-report (life history and personality inventory) and laboratory measures of aggression and impulsivity; measures of 5-HT will include measures related to the 5-HT Transporter. In Phase I of this project, twins will be administered a variety of questionnaires realted to impulsivity and aggression and other related behavioral variables. In Phase II, 420 twin (140 same sexed MZ, 140 same sexed DZ, and 140 opposite sexed DZ if gender differences in genetic influences are detected in Phase I or 210 same sexed Mzand 210 same sexed DZ if no gender differences in genetic influence are detected in Phase I) pairs will be studied in our Clinical Neuroscience Research Unit at The University of Chicago. Data will be collected from various experimental procedures, including laboratory analog assessments of aggression (Point Subtraction Aggression Paradigm: PSAP, Taylor Aggression Paradign: TAP, and Self Aggression Paradigm: SAP) and impulsivity (Immediate Memory Task: IMT, Go-Stop Task: GST, and the Single Key Impulsivity Paradigm: SKIP) Platelet 5-HT Transporter structure (i.e., number of 5-HTT binding sites: Bmax), function (i.e., velocity of 3H-5-HT Uptake: Vmax), and genotype (5-HTT Promoeter DNA Polymorphism) will be obtained to determin whether measures of serotonergic function demonstrate evidence of heritability and to examine the nature of a genetice influence on the inverse phenotypic correlation between 5-HT and aggression/impulsivity previously established over two decades of previous research. CRC resources are requested primarily for ancillary services in obtaining blood samples for Platelet 5-HT Transporter Binding/Uptake Velocity and in obtaining blood samples for Platelet 5-HT Transporter Binding/Uptake Velocity and in obtaining blood samples for DNA Extraction for confirmation zygosity status and for genotyping of 5-HT Transporter polymorphisms.