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中文摘要
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这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者(PI)可能从另一个NIH来源获得了主要资金, 因此可以在其他CRISP条目中表示。所列机构为 研究中心,而研究中心不一定是研究者所在的机构。 生殖科学司就与了解人类生殖和控制生殖疾病和生育力有关的生殖生物学方面进行基础和应用研究。 此外,该部门,作为俄勒冈州健康与科学大学的一部分,提供培训的个人进入科学为导向的职业生涯(例如,博士前和博士后研究员,妇女生殖健康研究[WRHR]学者计划的新教师,OB/GYN)和其他人的研究经验(例如,学校教师)。 最后,该部门作为区域,国家和国际生殖研究资源,特别是当它涉及到非人类灵长类动物。 该司科学家的研究(博士R.L. Stouffer,Head)专注于了解控制生殖功能的中枢(神经)和外周(内分泌,旁分泌和自分泌)机制,主要是女性。 研究项目跨越生殖的连续体,从配子(卵子和精子)发育开始,到后代的出生和喂养结束。 在所有实验室中,一个普遍的主题是利用旧大陆的猴子作为与人类生殖直接相关的整个动物、细胞和分子研究的模型。 通过更好地了解基本的生殖过程,研究人员正在考虑生殖障碍的病因和潜在的治疗方法,以及避孕的新方法。 此外,研究人员正在考虑通过辅助生殖技术进行未来生物医学研究的独特非人类模型,包括灵长类动物胚胎干细胞的研究和应用。 许多进展可以直接转化为妇女健康、癌症、糖尿病、心血管研究、老龄化、肥胖、神经科学和行为等问题。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Division of Reproductive Sciences conducts basic and applied research on aspects of reproductive biology relevant to understanding human reproduction and to controlling reproductive disorders and fertility. In addition, the division, as part of the Oregon Health & Science University, provides training for individuals entering science-oriented careers (e.g., pre- and postdoctoral fellows, new faculty in the Women's Reproductive Health Research [WRHR] scholar program, OB/GYN) and research experience for others (e.g., school teachers). Finally, the division serves as a regional, national and international resource for reproductive research, especially as it relates to nonhuman primates. The research of Division scientists (Dr. R.L. Stouffer, Head) focuses on understanding the central (neural) and peripheral (endocrine, paracrine, and autocrine) mechanisms controlling reproductive function, primarily in females. Research projects span the continuum of reproduction that begins with gamete (egg and sperm) development and ends with the birth and nursing of an offspring. A general theme apparent in all laboratories is the utilization of Old World monkeys as a model for whole animal, cellular and molecular studies of direct relevance to human reproduction. Through a better understanding of basic reproductive processes, investigators are considering the etiology and potential treatment of reproductive disorders, as well as novel approaches for contraception. Also, researchers are considering unique nonhuman models for future biomedical research through assisted reproductive technologies, including the study and application of primate embryonic stem cells. Many advances can be directly translated to issues in women's health, cancer, diabetes, cardiovascular research, aging, obesity, neuroscience and behavior.
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Hyperandrogenemia, Diet and Female Reproductive Health
PROJECT 2: OVARIAN AND UTERINE RESPONSES TO ANDROGEN AND DIET
Hyperandrogenemia, Diet and Female Reproductive Health
Hyperandrogenemia, Diet and Female Reproductive Health
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