Center For Education and Research in Therapeutics

描述(由申请人提供)：宾夕法尼亚大学治疗学教育和研究中心(PennCERT)建议加强和扩大其基础设施，同时开展研究和教育计划，以更有针对性地推进治疗学。PennCERT的主题将继续是传染病(抗感染治疗)，并增加以下新的分主题(即，我们可以成为整个CERT网络的资源的方法学重点领域)：1)药物流行病学，2)患者安全，3)健康信息技术。我们特别建议： 1.建立和加强我们的研究和教育中心及其协调的基础设施；继续积极参与国家CERT计划；继续我们的微型赠款计划，资助解决相关治疗问题的研究和支持R01应用程序开发的先导性研究；并保持一系列令人印象深刻的数据资源，供PennCERT和其他CERT的研究人员访问。 2.进行研究，以改善关于使用和影响的决定的基本证据基础 抗感染药。 3.实施和评估旨在改善门诊和医院抗感染药物使用情况的干预措施 特别是住院环境，无论是地方、地区还是全国。 4.开展研究方法、医学文献批判性评价和治疗方面的教育 针对多个受众的决策，包括医学生、医学研究生、 和医疗保健专业人士。 5.传播和翻译我们的工作成果，包括出版物和演示文稿：i)为 科学界/专业界；二)食品和药物管理局、AHRQ、其他CERT等；三)公众，在 伦纳德·戴维斯研究所完善的传播计划。 目前PennCERT申请的新功能包括：新的研究人员(前PennCERT受训人员，现已接受教职)；增加调查人员，以加强我们在卫生经济学、生物医学信息学和空间建模方面的专业知识；与教职员工和费城儿童医院计划的一个重大项目，更加关注儿科；更加重视研究和教育，旨在开发、实施和评估将最佳抗菌药物实践的证据转化为日常实践的新项目，特别是在医院环境中；四个更大的研究项目，可能是因为现在可用的资源增加；以及随着早期项目的完成，未来几年在选择项目方面的灵活性增加。

DESCRIPTION (Provided by the Applicant): The University of Pennsylvania Center for Education and Research on Therapeutics (PennCERT) proposes to reinforce and expand its infrastructure, while conducting research and educational programs to advance therapeutics in an even more focused way. The theme of the PennCERT will continue to be infectious diseases (anti-infective therapy) with the following new subthemes (i.e., areas of methodologic focus where we can be a resource for the whole CERT network): 1) pharmacoepidemiology, 2) patient safety, and 3) health information technology. In particular, we propose to: 1. Build on and enhance our research and educational center with its coordinated infrastructure; continue our active participation in the national CERTs program; continue our mini-grant program that funds studies addressing relevant therapeutic questions and pilot studies that support the development of R01 applications; and maintain an impressive series of data resources, accessible to investigators from the PennCERT and other CERTs. 2. Conduct research to improve the underlying evidence base for decisions about the use and effects of anti-infectives. 3. Implement and evaluate interventions aimed at improving the use of anti-infectives in outpatient and especially inpatient settings, locally, regionally, and nationally. 4. Conduct education in research methods, critical appraisal of the medical literature, and therapeutic decisionmaking targeting multiple audiences, including medical students, graduate medical trainees, and health care professionals. 5. Disseminate and translate the results of our work, including publications and presentations: i) for the scientific/professional community; ii) the FDA, AHRQ, other CERTs, etc.; and iii) the public, building on the well-developed dissemination program of the Leonard Davis Institute. New features of the current PennCERT application include new investigators (former PennCERT trainees who have now accepted positions as faculty); investigators added to strengthen our expertise in health economics, biomedical informatics, and spatial modeling; an increased focus on pediatrics, with faculty and a major project planned at Children's Hospital of Philadelphia; an increased focus on research and education intended to develop, implement, and evaluate novel programs for translating evidence on optimal antimicrobial drug practices into everyday practice, particularly in hospital settings; four larger research projects, possible because of the increased resources now available; and an increased flexibility in choice of projects in future years, as earlier projects are completed.