Socio-moral processing in psychopathy and substance abuse

描述（由申请人提供）：精神病和药物滥用是严重的、共病的临床疾病，与重大的民事和刑事破坏有关。在了解药物滥用和精神病如何预测机构行为、犯罪再犯和治疗结果方面取得了重大进展。然而，就这两种疾病的神经生物学以及它们如何相互作用而言，人们知之甚少。精神病和药物滥用通常与决策能力受损，特别是道德决策能力受损有关。本提案的目的是研究与精神变态和药物滥用的道德决策相关的共同和独特的神经系统。结构和功能成像方法将用于绘制与处理语言和基于图像的道德决策范式相关的神经结构，这些道德决策范式是通过精神变态得分和药物滥用措施分层的。这项研究将利用一种移动核磁共振系统，该系统将被部署到监狱设施中，以收集有精神病和药物滥用问题的罪犯的代表性样本。对这一样本的详细分析将使我们能够描绘出与精神病态和药物滥用中道德决策受损相关的神经认知系统。这项研究可能会对旨在治疗这些疾病的认知行为疗法的发展产生直接影响。公共卫生相关：犯罪的社会成本为每年1.33万亿美元，即美国男女老少人均4400美元。心理健康和成瘾障碍是与犯罪行为相关的一些最常见的状况。这一提议旨在了解与有精神健康和成瘾问题的男性罪犯的道德决策相关的大脑系统。这项研究旨在帮助减轻社会中心理健康、成瘾和犯罪的负担。

DESCRIPTION (provided by applicant): Psychopathy and substance abuse are severe, co-morbid clinical disorders associated with significant civil and criminal disruption. Significant strides have been made in understanding how substance abuse and psychopathy predict institutional behavior, criminal recidivism, and treatment outcome. However, little is understood in terms of the neurobiology of these two disorders and how they interact. Psychopathy and substance abuse are commonly associated with impaired decision-making in general, moral decision-making in particular. The purpose of the present proposal is to examine the common and unique neural systems associated with moral decision-making in psychopathy and substance abuse. Structural and functional imaging methods will be used to map the neural architecture associated with processing linguistic and picture based moral decision-making paradigms in male offenders stratified by psychopathy scores and substance abuse measures. This research will utilize a mobile MRI system that will be deployed to prison facilities to collect representative samples of offenders with psychopathy and substance abuse problems. Detailed analyses of this sample will enable us to delineate the neurocognitive systems associated with impaired moral decision-making in psychopathy and substance abuse. This research may have a direct impact on the development of cognitive behavioral therapies designed to treat these conditions. PUBLIC HEALTH RELEVANCE: The societal cost of crime is $1.33 Trillion per year or $4400 per every man, woman, and child in the United States. Mental health and addiction disorders are some of the most common conditions associated with criminal behavior. This proposal seeks to understand the brain systems associated with moral decision-making in male offenders with mental health and addiction problems. This research is designed to help reduce the burden of mental health, addiction, and crime in society.