NICHD Maternal Fetal Medicine Units Network

描述（由申请人提供）：西北大学医学院的母胎医学科有浓厚的兴趣继续作为母胎医学单位多中心网络的成员。我们再次希望参加采用共同方案的临床试验，重点是早产和导致新生儿死亡和发病的其他情况。本申请描述了西北纪念医院（NMH）和埃文斯顿西北医疗保健（ENH）网络活动中MFM单位的合作努力计划。NMH和ENH是西北大学范伯格医学院的两个主要教学附属机构。这两个设施的妇产科部门的联合活动包括对医学生和住院医师的教育以及研究。我们已经证明了我们在联合开展和参与随机试验和多中心研究方面的能力，这些研究涉及孕妇及其新生儿的详细研究程序。在MFMU网络的当前周期中，ENH通过一项网络协议被添加为西北招募网站，目前正在两个网络协议上进行招募。本次提交的计划是继续开展网络试验合作，并将其扩展到所有正在进行的研究。我们相信我们的优势在于我们在两个学术机构的大型患者群，具有良好的研究合作记录，以及我们致力于创新的教师能够为网络的研究议程的发展和优先级提供新的方向。此外，我们拥有必要的研究基础设施，不仅能够招募和随访高风险患者，还能够招募和随访私人和贫困患者，这将最大限度地提高MFMU网络结果对整个围产期不良结局风险人群的普遍性。我们致力于与成员单位和网络工作人员在研究设计、方案实施、患者招募、数据分析和发表等方面开展合作。与公共卫生的相关性-我们计划从两个大型学术医学中心的不同患者人群中招募患者，参与多中心临床试验，调查临床产科的重要问题，例如该国持续的高早产率。我们还计划以合作方式参与研究设计和网络的其他功能。通过这种方式，我们希望为当前的临床困境提供答案，这将导致更好的患者护理和改善新生儿及其母亲的临床结局。

DESCRIPTION (provided by applicant): The Section of Maternal-Fetal Medicine at Northwestern University Medical School has a strong interest in continuing as a member of the multicenter Network of Maternal-Fetal Medicine Units. We again wish to participate in clinical trials utilizing common protocols, with emphasis on the areas of preterm delivery and other conditions leading to neonatal mortality and morbidity. This application describes a plan for the cooperative efforts of the MFM units at both Northwestern Memorial Hospital (NMH) and at Evanston Northwestern Healthcare (ENH) in Network activities. NMH and ENH are the two primary teaching affiliates for the Northwestern University Feinberg School of Medicine. Combined activities of the Departments of Obstetrics and Gynecology at these two facilities include education of medical students and residents, as well as research. We have demonstrated our capabilities in jointly conducting and participating in randomized trials and multicenter studies that involved detailed study procedures for both pregnant women and their neonates. During this current cycle of the MFMU network, ENH was added as a Northwestern recruitment site through a subcontract arrangement, and recruitment is currently occurring on two network protocols. The plan for this submission is for cooperation in network trials to continue and to be expanded to all ongoing studies. We believe our strengths lie in our large patient base in two academic facilities with a proven record of cooperation in research, and our committed, innovative faculty capable of contributing new directions to the development and prioritization of a research agenda for the Network. Furthermore, we have the requisite research infrastructure that enables the recruitment and follow-up of not just high-risk patients, but private as well as indigent patients that will maximize the generalizability of MFMU Network results to the entire population at risk for adverse perinatal outcomes. We are committed to working cooperatively with member units and network staff in the areas of study design, protocol implementation, patient recruitment, data analysis and publication. Relevance to public health-We plan to recruit patients from a diverse patient population at two large academic medical centers to participate in multicenter clinical trials investigating important problems in clinical obstetrics, such as the persistent high rate of preterm birth in this country. We also plan to participate in study design and other functions of the network in a cooperative fashion. In this way we hope to provide answers to current clinical dilemmas, which will result in better patient care and improved clinical outcomes for both neonates and their mothers.