Clinical Trial Network: Southwest Node

描述（由申请人提供）：新墨西哥州酒精中毒，药物滥用和成瘾中心（CASAA）的大学提交了NIDA临床试验网络（CTN）的西南节点更新的申请。在最初的资助期间，西南节点为CTN的研究活动做出了大量具有成本效益的贡献。该节点已成功地完成了五个协议，以及一个单一的网站适应这些协议之一（求职者研讨会，协议0020）在治疗方案的美洲原住民。除了参与议定书之外，联络点还在议定书制定、培训和委员会工作等领域作出了重要贡献。在CCTN提供的最新节点性能指标（2005年8月至2006年7月）中，西南节点在与试验性能相关的所有6项节点性能指标上的得分均达到或高于全国平均水平。该节点为推进少数民族和其他服务不足人群的成瘾治疗临床科学做出了杰出贡献，占CTN协议所有西班牙裔参与者的17%，占所有美洲原住民参与者的54%，其中包括102名美洲原住民参加了0020协议的改编。西南节点也一直在积极传播CTN为基础的治疗实践，我们所有的CTP已经采用了一个或多个新的循证治疗。西南节点的特殊优势包括：1）行为治疗和药物治疗的临床试验的良好记录; 2）在开发和评估成瘾创新治疗方面的长期经验; 3）具有挑战性的人群，包括共同发生的疾病，无家可归者，离家出走的青少年和孕妇的丰富经验; 4）传播和培训研究方面的专业知识; 5）Node CTP中少数民族患者的高度集中（70%）;以及6）西南边境的地理代表性。为了说明CTN范围内的研究，可以从西南节点开始，一个协议的概念，提出了一个务实的试验双硫仑可卡因依赖使用药物管理模型。相关性：这项工作支持CTN的使命，即利用科学方法在现实世界中对药物滥用治疗干预措施进行严格的多地点试验，并促进循证实践的传播，以改善美国的药物滥用治疗。

DESCRIPTION (provided by applicant): The University of New Mexico Center on Alcoholism, Substance Abuse, and Addictions (CASAA) submits an application for renewal of the Southwest Node of the NIDA Clinical Trials Network (CTN). In its initial funding period, the Southwest Node has made a substantial and cost-effective contribution to the research activities of the CTN. The Node has successfully completed five protocols, as well as a single-site adaptation of one of these protocols (Job Seekers Workshop, protocol 0020) at a treatment program for Native Americans. Beyond participation in protocols, the Node has made important contributions in the areas of protocol development, training, and committee work. In the most recent Node performance measures available from the CCTN (August 2005-July 2006), the Southwest Node scored at or above national average on all 6 of the Node performance measures relating to trial performance. The Node has made an outstanding contribution to advancing the clinical science of addictions treatment in minority and other underserved populations, contributing 17% of all Hispanic participants in CTN protocols, and 54% of all Native American participants, including 102 Native Americans enrolled in the adaptation of protocol 0020. The Southwest Node has also been highly active in disseminating CTN-based treatments into practice, and all of our CTPs have already adopted one or more new evidence-based treatments. Particular strengths of the Southwest Node include: 1) a well-established track record of clinical trials for both behavioral treatments and pharmacotherapies; 2) longstanding experience in the development and evaluation of innovative treatments for addictions; 3) substantial experience with challenging populations including co-occurring disorders, the homeless, runaway adolescents, and pregnant women; 4) expertise in research on dissemination and training; 5) a high concentration (70%) of minority patients in the Node CTPs; and 6) geographic representation of the border Southwest. To illustrate CTN-wide research that could be initiated from the Southwest Node, a protocol concept is described proposing a pragmatic trial of disulfiram for cocaine dependence using a medication management model. Relevance: This work supports the CTN's mission to improve drug abuse treatment in the United States using the methods of science to conduct rigorous multi-site trials of substance abuse treatment interventions in real-world settings, and to facilitate the dissemination of evidence-based practices.