DIET AND GENOTYPE IN PRIMATE ATHERSCLEROSIS: VETERINARY SERVICES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是“灵长类动脉粥样硬化的饮食和基因型”项目SPID 0044的一部分。 核心单位C负责维护纯种狒狒群体，管理繁殖组，并使用狒狒进行实验程序。 菌落维护包括日常护理，即，喂食指定的饲料、清洁笼舍、观察动物的疾病体征、治疗患病动物以及维护动物数据库记录。 繁殖群体管理包括维持母畜分配、监测母畜妊娠、在动物数据库中记录出生情况以及从殖民地剔除无生产力的动物。 实验程序包括施用高胆固醇、高脂肪饮食挑战、血液收集、股动脉活检、肝活检、肌肉活检、脂肪组织活检和血流介导的血管舒张。动物管理员负责动物的日常维护。兽医或兽医技术人员提供医疗保健，准备实验饮食，并负责实验程序。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is part of the Program Project "Diet and Genotype in Primate Atherosclerosis", SPID 0044. Core Unit C is responsible for maintaining the pedigreed baboon colony, managing the breeding groups, and conducting the experimental procedures using baboons. Colony maintenance includes daily care, i.e., feeding assigned diets, cleaning cages, observing animals for signs of illness, treating sick animals, and maintaining animal database records. Breeding colony management includes maintaining sire-dam assignments, monitoring dams for pregnancies, recording births in the animal database, and culling unproductive animals from the colony. Experimental procedures include administration of the high cholesterol, high fat dietary challenge, blood collections, femoral artery biopsies, liver biopsies, muscle biopsies, adipose tissue biopsies, and flow mediated vasodilation. Animal caretakers are responsible for animal maintenance on a daily basis. Veterinarians or veterinary technicians provide health care, prepare experimental diet, and are responsible for experimental procedures.