POTENTIAL REGULATION OF FGF-21 BY FASTING AND DIET-INDUCED KETOSIS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究将研究最近发现的一种称为成纤维细胞生长因子21（FGF-21）的代谢调节剂的血液水平的潜在变化，以应对健康成年人饮食的变化。FGF-21的给药已显示出改善糖尿病小鼠和猴模型中的循环葡萄糖和脂质水平。此外，暴露于FGF-21改善了体外胰腺胰岛素分泌细胞的功能。FGF-21可能在人体代谢的生理调节中发挥重要作用。然而，FGF-21循环水平变化的方式尚不清楚。该假设是，在健康成人中，FGF-21水平将对饮食变化做出反应，特别是禁食和饮食诱导的酮症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will examine the potential changes in the blood levels of a recently discovered metabolic regulator called fibroblast growth factor 21 (FGF-21) in response to changes in diet in healthy adults. Administration of FGF-21 has been shown to improve circulating glucose and lipid levels in mouse and monkey models of diabetes. In addition, exposure to FGF-21 improves the function of the insulin secreting cells of the pancreas in vitro. It is possible that FGF-21 plays an important role in physiological regulation of metabolism in humans. However, the way in which circulating levels of FGF-21 change is not known. The hypothesis is that in healthy adults FGF-21 levels will respond to changes in diet, particularly fasting and diet-induced ketosis.