SEX-BASED COMPARISION OF THE ADRENERGIC REGULATION OF SUBSTRATE METABOLISM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 男性和女性在身体优先使用脂肪和碳水化合物作为燃料来源的方式上有所不同。这在应对身体S能量需求和/或葡萄糖需求增加的情况下尤其明显。这方面的一个例子是在锻炼过程中。这些基于性别的燃料利用模式差异是如何实现的，目前尚不清楚。肾上腺素和去甲肾上腺素(称为儿茶酚胺)是两种重要的荷尔蒙，它们参与调动体内储存的脂肪和碳水化合物。一旦动员起来，脂肪或碳水化合物就可以用作燃料。与男性相比，女性似乎能够更好地调动脂肪来应对这些荷尔蒙。因此，这项研究将更详细地研究这些脂肪动员激素中的一种是如何增加女性比男性更多的脂肪释放的。这将需要将荷尔蒙和/或类似荷尔蒙的化合物低水平地注入手臂静脉，这些化合物可以模仿或阻止动员脂质的荷尔蒙的一些效果。为了观察这些荷尔蒙/荷尔蒙样化合物对多少脂肪和多少葡萄糖的动员，将向同一臂静脉注入自然产生的脂肪和葡萄糖的示踪物。血液样本将从手静脉中提取，以查看血液中这些示踪剂的水平，以及激素、脂肪和葡萄糖代谢物的水平。要抽取血样，需要将手放在温暖的盒子里加热。在整个研究过程中，还将收集呼气样本，以查看动员起来的脂肪和碳水化合物中有多少被用作燃料。这项研究的结果将帮助我们更好地了解男性和女性对燃料使用的控制方式是如何不同的。因此，重要的信息将被获得，以帮助我们更好地了解肥胖和糖尿病等情况，在这些情况下，葡萄糖和脂肪的利用可能会异常。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Men and women differ in the way their bodies prioritize the use of fat and carbohydrate as fuel sources. This is seen particularly in response to situations where there is an increase in the body s energy requirements, and/or glucose requirements. An example of this is during exercise. How these sex-based differences in the pattern of fuel utilization are achieved is not known. Two important hormones that are involved in mobilizing fat and carbohydrate from the bodies stores are epinephrine and norepinephrine (called catecholamines). Once mobilized, the fat or carbohydrate can be used as a fuel. Women appear to be better able to mobilize fat in response to these hormones compared to men. This study will, therefore, look in more detail at how exactly one of these lipid mobilizing hormones increase fat release more in women than men. This will require a low level infusion of the hormone, and/or hormone-like compounds that either mimic or stop some of the effects of the lipid-mobilizing hormone, into an arm vein. To look at how much fat versus how much glucose is mobilized in response to these hormone/hormone-like compounds, infusions will be made into the same arm vein of naturally occurring tracers of fat and glucose. Blood samples will be taken from a hand vein to look at the levels of these tracers in the blood as well as levels of hormones and fat and glucose metabolites. To draw blood samples, the hand is heated in a warm box. Breath samples will also be collected throughout the study to look at how much of the fat and carbohydrate that is mobilized is used as a fuel. Results from this study will help us to gain a better understanding of how fuel use is controlled differently in men and women. Thus, important information will be gained to better help us understand conditions such as obesity and diabetes where there can be abnormalities in glucose and lipid utilization.