General Clinical Research Center

GCRC是斯坦福大学医学院的主要临床研究机构。这 建议续期五年，为期45-49年的研究经费。它总共涉及138个 协议和来自19个大学系的147名调查人员。我们的目标是提供最佳的 进行以病人为中心的研究的设施，将基本的科学知识转化为 更好地了解和治疗人类疾病，并培训临床卫生专业人员 研究。斯坦福大学医院目前的空间提供了一位出色的住院患者和 门诊GCRC设施，一个早产儿研究项目利用分散的病床在 毗邻露西尔·帕卡德儿童医院。七大计划和调查人员 这项建议的核心是： (1)TLR激动剂CpG7909联合局部瘤内注射的L/Ⅱ期研究 复发性低级别淋巴瘤的放射治疗(罗纳德·利维) (2)人类对自然感染和疫苗的免疫反应(Cornelia J.Dekker)。 (3)周围动脉疾病中一氧化氮合酶通路的治疗操作(约翰·P·库克)。 (4)结直肠癌的新治疗方法(Branimir I.Sikic)。 (5)精神病患者的下丘脑-垂体-肾上腺轴(艾伦·沙茨伯格)。 (6)神经成像和神经发育结果(大卫·史蒂文森)。 (7)对侧肾切除后的老化肾脏(Bryan D.Myers)。

The GCRC is the major clinical research facility for Stanford University School of Medicine. This proposal is for a five year renewal, for years 45-49 of this research grant. It involves a total of 138 protocols and 147 investigators from 19 university departments. Our goals are to provide an optimal facility for the conduct of patient oriented research, to translate basic scientific knowledge into a better understanding and treatment of human diseases, and to train health professionals in clinical research. Current space in Stanford University Hospital provides an outstanding inpatient and outpatient GCRC facility, and a premature infant research program utilizes scatter beds in the adjacent Lucile Packard Children's Hospital. The seven major programs and investigators which form the core of this proposal are: (1) A Phase l/ll Study of Intratumoral Injection of CpG7909, a TLR Agonist, Combined with Local Radiation in Recurrent Low Grade Lymphomas (Ronald Levy). (2) Human Immune Response to Natural Infections and Vaccines (Cornelia J. Dekker). (3) Therapeutic Manipulation of the NOS Pathway in Peripheral Arterial Disease (John P. Cooke). (4) New Therapeutic Approaches for Colorectal Cancers (Branimir I. Sikic). (5) The Hypothalamic-Pituitary-Adrenal Axis in Psychotic Depression (Alan Schatzberg). (6) Neuroimaging and Neurodevelopmental Outcome (David Stevenson). (7) The Aging Kidney after Contralateral Nephrectomy (Bryan D. Myers).