General Clinical Research Center

超出空间 提供了 UVA GCRC的临床研究已进入第31个年头，我们请求在第33 - 37年提供支持。我们 GCRC在神经内分泌学、变态反应、生殖医学、免疫治疗、 癌症和糖尿病。这些持续存在。在过去的2年里，我们吸引了一批新的GCRC干部 来自心脏病学，血管生物学和替代医学中心的研究人员在 护理学院。随着最近在我们的部门招聘新的研究密集型领导， 心血管内科、血液科和肿瘤科，以及我们的精神病学和行为学系 医学，我们预计我们的研究计划的持续增长和活力。在过去的两年里，我们 我们的核心分析程序也进行了重大升级，从而促进了样品通量， > 100，000/年，同时腾出人员时间来实施额外的分析服务。我们发起了一个新的 GCRC成像实验室允许研究糖尿病、胰岛素抵抗、 以及PCOS与心、肌、肾等多器官微血管灌注的关系。 弗吉尼亚大学全球资源中心的生产力记录非常好（在过去4年中发表了170多篇出版物）。其 运动，信息学和生物数学核心一直是国家领导人在他们的创新支持， 临床研究。GCRC拥有NIH资助的稳定的研究人员核心， 通过我们的教育和指导计划，发展另一代熟练的临床 investigators.我们为我们的CAP和K奖获奖者感到特别自豪。 在过去的3年里，我们已经看到（作为一个国家的趋势）在门诊研究的增长， 住院病人的研究，特别是那些涉及24小时采血的研究已经减少。我们有亲- 积极开始与UVA卫生系统合作，计划重新设计GCRC，扩大空间， 为门诊病人提供更大的可及性，以适应目前和预计的使用。

EXCEED THE SPACE PROVIDED. Clinical investigation at the UVA GCRC is in its 31st year, and we request support for years 33-37. Our GCRC has longstanding strengths in neuroendocrinology, allergy, reproductive medicine, immunotherapy of cancer, and diabetes. These persist. In the past 2 years we have attracted a new cadre of GCRC investigators from Cardiology, vascular biology, and from the Center for Alternative Medicine program in the School of Nursing. With the recent recruitment of new research intensive leadership in our divisions of Cardiovascular Medicine, Hematology and Oncology, and our Department of Psychiatry and Behavioral Medicine, we anticipate continued growth and vitality of our research programs. In the past 2 years, we have also had major upgrades in our core assay program thereby facilitating sample throughput to >100,000/yr while freeing personnel time to implement additional analytical services. We have initiated a new GCRC imaging laboratory to allow studies of endothelial dysfunction in setting of diabetes, insulin resistance, and PCOS and microvascular perfusion in multiple organs including heart, muscle and kidney. The UVA GCRC has enjoyed an excellent record of productivity (>170 publications over the past 4 yrs). Its exercise, informatics and biomathematics cores have been national leaders in their innovative support for clinicalinvestigations. The GCRC enjoys a stable core of NIH-funded established investigators and is developing through our educational and mentoring programs another generation of skilled clinical investigators. We are particularly proud of our CAP and K award winners. During the last 3 years, we have seen (as has been a national trend) a growth in outpatient studies while inpatient studies, particularly those that have involved 24 hr blood sampling, have decreased. We have pro- actively begun working with the UVA Health System to plan a redesigned GCRC with expanded space and greater accessibility for outpatients that would accommodate current and projected usage.