RESTORATION OF INTEGRIN FUNCTION IN CHRONIC MYELOGIC LEUKEMIA (CML)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是了解为什么白血病细胞与正常骨髓细胞相比以不受调节的方式生长，以及生物制剂干扰素如何恢复白血病细胞的正常生长特性。 来自白血病患者的骨髓形成细胞对能够调节来自正常个体的骨髓形成细胞的生长的信号没有适当的反应。 正常骨髓细胞表面的某些粘性蛋白质称为整合素，它对调节生长很重要，在白血病细胞中功能异常，但它们的功能可以通过干扰素恢复正常。 在这项研究中，我们将试图发现为什么这些蛋白质在白血病细胞中与正常细胞相比功能异常，以及干扰素如何纠正这种异常。 这些研究的结果可能有助于我们设计改进的白血病治疗方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to understand why leukemia cells grow in an unregulated manner compared with normal marrow cells and how the biological agent interferon restores normal growth characteristics of leukemia cells. Marrow forming cells from patients with leukemia do not respond appropriately to signals capable of regulating the growth of marrow forming cells from normal individuals. Certain sticky proteins on the surface of normal marrow cells called integrins, which are important for regulation of growth, function abnormally in leukemia cells but their function can be restored to normal by interferon. In this study we will try to discover why these proteins function abnormally in leukemia cells compared with normal cells, and how interferon corrects this abnormality. Results from these studies may help us to design improved treatments for leukemia.