SC COBRE for Developmentally Based Cardiovascular Diseases

COBRE第三阶段的更新旨在维持在NCRR资助的第一个十年期间建立的研究基础设施。我们的COBRE“心血管发育生物学中心”已成为国家认可的合作中心，在发育相关的心血管疾病方面具有独特优势。三个基本主题定义了该中心的研究：了解正常和异常心脏和血管发育的机制;调查成人心血管疾病的发展基础;并将正常心血管发育生物学的原则应用于再生医学或基于干细胞的组织工程。COBRE在实现这三个“从摇篮到坟墓”目标方面的成就包括招聘8名新教师，指导和培训23名COBRE目标教师，以及开发3个研究核心设施。方案成果包括28个独立的研究奖，以目标教师，>410同行评议的出版物，经济卓越的南卡罗来纳州中心（COEE）授予六个赋予椅子在再生医学和先进的组织生物制造与克莱姆森和南卡罗来纳州，一个NSF研究基础设施改善奖，以建立一个组织制造全州联盟的大学合作伙伴关系共享，参与成功更新全州范围内的再生医学INBRE奖，并资助Leducq基金会的翻译奖，以创建跨大西洋研究网络，探索瓣膜疾病的遗传机制。对于此PSO应用程序，该中心在未来五年内过渡到独立于NIH/NCRR支持的计划是增强和升级我们的核心技术，提高其竞争力以吸引更多的使用（和成本回收），并促进与我们中心的新研究合作，这可以导致提交有竞争力的研究申请并扩大我们在全州范围内的推广，特别是其他IDEA中心。提出了一项为期五年的十步战略计划，包括实施费用结构、试点项目、外展活动和项目开发，以维持CDBC/COBRE中心及其三个科学核心（形态学、成像和仪器核心、蛋白质基因组学和生物信息学核心和基因功能核心）。由MUSC心血管COBRE的创始董事领导的行政核心是项目协调员和内部咨询委员会的所在地。他们将共同作为中心的主要业务部门。一个外部咨询委员会将对中心的进展情况进行持续评估和评价。研究副教务长和医学院院长的机构承诺-超过100万美元-有助于确保该中心的方案增长发展和长期可持续性。

This COBRE Phase III renewal is aimed at sustaining the research infrastructure built during the first ten years of NCRR funding. Our COBRE "Cardiovascular Developmental Biology Center" has become a nationally recognized, collaborative center with exclusive strengths in developmentally-related, cardiovascular diseases. Three underlying themes define the Center's research: understanding mechanisms of normal and abnormal heart and vascular development; investigating the developmental basis of adult cardiovascular diseases; and applying the principles of normal cardiovascular developmental biology to regenerative medicine or stem cell-based, tissue engineering. COBRE accomplishments towards these three "cradle to grave" goals include the recruitment of 8 new faculty, mentoring and training of 23 COBRE target faculty, and the development of 3 research core facilities. Programmatic outcomes include 28 independent research awards to target faculty, >410 peer reviewed publications, the State of South Carolina Center of Economic Excellence (COEE) awarding six endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication shared in partnerships with Clemson and the University of South Carolina, an NSF Research Infrastructure Improvement award to establish a statewide alliance in tissue fabrication, participation in the successful renewal of a statewide INBRE award in regenerative medicine, and funding of a translational award by the Leducq Foundation to create a Transatlantic Research Network exploring genetic mechanisms for valve diseases. For this PSO application, the plan for the Center transitioning to being independent of NIH/NCRR support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A ten Step, five year strategic plan including implementing fee structures, pilot projects, outreach activities and programmatic development is proposed to sustain the CDBC/COBRE center and its three scientific cores (Morphology, Imaging and Instrumentation Core, Proteogenomics and Bioinformatics Core, and Gene Function Core). An Administrative Core, led by the founding director of MUSC's Cardiovascular COBRE, is home to the Program Coordinator and the Internal Advisory Committee. Together, they will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Associate Provost for Research and Dean of the College of Medicine - exceeding one million dollars - help ensure programmatic growth development, and long-term sustainability of the Center.