Case Urology Translational Research Training Program (CUTRTP)

描述（由申请人提供）：泌尿系统疾病，包括生殖泌尿道（GU）的状况，可以是先天性或获得性的，恶性或良性的，内科或外科的。2000年，仅前4名泌尿系统疾病就有超过2500万人次就诊于医生和医院;然而，解决这些问题的研究组合滞后。大多数专家认为缺乏合格的科学家和泌尿科医生-科学家是最重要的促成因素。因此，凯斯西储大学（CWRU）医学中心（CWRU UI）的泌尿外科研究所的成立，其首要目标是迅速扩大转化研究和培养新一代科学家和外科医生科学家。通过本提案中要求的资金，我们建议建立CWRU泌尿外科转化研究培训计划（CUTRTP），以扩大我们目前对每年2至6名博士后博士或研究生医学博士的培训支持（5年内共12名），在两个科学家轨道上（博士，博士，博士和博士）。或者医学博士候选人）和外科医生科学家（MD候选人）。所有候选人都必须有强烈的愿望，追求学术医学的职业生涯，专注于转化研究。理想的成功博士候选人将完成他们的培训，并可能完成0-1年的博士后工作。理想的成功的医学博士候选人将获得他们的医学博士学位，并在ACGME认证的项目中完成泌尿科，妇科或家庭医学的住院医师，并有研究历史。 CUTRTP基于3个培训支柱：1）为学员提供基础和临床导师的翻译重点，以改善患者护理和结果2）从CWRU其他领域招募顶级研究人员作为未来研究者的培训师，3）教学和专业培训，由独立评估委员会评估里程碑。使用结构化的课程，我们建议培养一批科学家和外科医生，科学家专注于3个主要领域的转化泌尿学研究：a）泌尿生殖系统癌症，B）女性骨盆底疾病，和c）肥胖和糖尿病的泌尿系统并发症。所有学员将在2年的专门研究中获得相同的指导水平和承诺，并且必须与其他合格的学员竞争第二年的职位。来自15个部门的29名优秀培训师，累计NIH资金总额约为3000万美元，他们聚集在CUTRTP中，以确保选择，招聘，培训和交付一些最好的科学家和外科医生-科学家在泌尿系统疾病。 公共卫生相关性：泌尿系统疾病可能危及生命（包括肾癌和前列腺癌）或导致生活质量严重恶化（包括尿失禁）。随着美国人口老龄化，这些疾病可能会给患者和医疗保健系统带来更大的负担。该提案将确保培训和发展新的高素质科学家和外科医生-科学家，以确保继续研究泌尿系统疾病的新治疗策略，采用从工作台到床边的方法，最终改善患者护理。

DESCRIPTION (provided by applicant): Urological diseases which include conditions of the genito-urinary tract (GU) can be congenital or acquired, malignant or benign, and medical or surgical. Roughly more than 25 million visits to physicians and hospitals took place in 2000 for just the top 4 urologic conditions; however, the research portfolio to address them lags. Most experts would consider the shortage of qualified scientists and urologists-scientists as the most important contributing factor. Thus, the Urology Institute of the Case Western Reserve University (CWRU) Medical Center (CWRU UI) was created with the overarching goal of rapid expansion of translational research and training of a new generation of scientists and surgeon-scientists. Through the funding requested in this proposal we propose to establish the CWRU Urology Translational Research Training Program (CUTRTP), to expand our current support for the training of 2 to 6 postdoctoral PhD or postgraduate MDs, per year (12 total over 5-years), in two tracks of scientists (for Ph.D. or M.D. candidates) and surgeon-scientists (for MD Candidates). All candidates must have a strong desire to pursue a career in academic medicine focusing on translational research. The ideal successful PhD candidates will have completed their training and potentially, 0-1 years of postdoctoral work. The ideal successful MD candidates will have received their MD and completed residency in urology, gynecology, or family medicine at an ACGME accredited program, and have a history of research. The CUTRTP is based on 3 training pillars: 1) a translational focus for trainees with basic and clinica mentors to yield greater impact on improved patient care and outcomes 2) recruitment of the top researchers from other fields at CWRU as trainers of future investigators, 3) didactic and professional training, with milestones, evaluated by an independent Evaluation Committee. Using a structured curriculum, we propose to train a group of scientists and surgeon-scientists to focus on translational urology research in 3 main areas: a) genitourinary cancers, b) female pelvic floor disorders, and c) urological complications of obesity and diabetes. All trainees will receive the same level and commitment of mentoring throughout their 2 years of devoted research and must compete for the 2nd year position with other qualified trainees. A group of 29 outstanding trainers from 15 departments with a cumulative NIH-funding total of approximately $30 million have come together in the CUTRTP to ensure selection, recruitment, training, and delivery of some of the best scientists and surgeon-scientists in urological diseases. PUBLIC HEALTH RELEVANCE: Urological diseases may be life-threatening (including kidney and prostate cancers) or cause severe deterioration in quality of life (including urinary incontinence). As the U.S. population ages, these conditions will likely cause an even greater burden to patients and the healthcare system. This proposal would ensure training and development of new highly-qualified scientists and surgeon-scientists to ensure continued research into new treatment strategies for urological diseases using a bench to bedside approach to ultimately improve patient care.