Core A - Administrative Core

摘要 核心A--行政核心 拟议更新儿童白血病与环境综合研究中心 (Circle)，这是位于加州大学的儿童环境健康和疾病研究中心 加州伯克利分校旨在研究化学、遗传和表观遗传因素以及免疫状态 胎儿发育及其在儿童最常见癌症病因学中的作用 不同种族的人口。Circle包括三个研究项目和三个核心如下：项目1 (在子宫化学暴露、免疫状态和儿童白血病中)将评估特定的 在子宫内的化学品，如多氯联苯(PCBS)、多溴联苯醚(PBDEs)、 多环芳烃(PAHs)、氯代烃和烟草化学混合物，可以 影响胎儿免疫状态，以及它们对儿童急性淋巴细胞白血病(ALL)风险的联合影响； 项目2(在子宫暴露中确定儿童白血病的风险因素)将描述 怀孕期间从各种来源获得的母亲/胎儿暴露的广泛类别，包括污染， 饮食、药物和内源性过程通过对小分子和 反应性亲电加合物；项目3(产前暴露、构成遗传学、DNA甲基化和 儿童白血病)将使人们更清楚地了解环境和 遗传因素和免疫因素对儿童白血病DNA甲基化模式的影响 点；社区外联和翻译核心(COTC；核心B)将传播每个 向对儿童白血病病因感兴趣的不同受众进行项目；以及小鼠模型 Service Core(Core C)将在儿科急性呼吸道感染的动物模型中测试化学暴露的影响 淋巴细胞性白血病。核心A的主要目标是提供监督、协调和集成 中心活动；建立/管理外部咨询委员会；协调社区参与， 任命儿科健康专家并与之合作，支持以下领域的研究事业发展 中心结构内的新职业发展调查员。根据这些目标，核心A 将为所有项目和核心提供集中的行政和研究支助。

ABSTRACT Core A – Administrative Core The proposed renewal of the Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE), which is a Children’s Environmental Health and Disease Research Center based at the University of California, Berkeley is designed to study chemical, genetic, and epigenetic factors and immune status during fetal development and their roles in the etiology of the most common childhood cancer in a vulnerable and ethnically diverse population. CIRCLE includes three Research Projects and three Cores as follows: Project 1 (In Utero Chemical Exposures, Immune Status, and Childhood Leukemia) will assess the interplay of specific in utero chemicals such as polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), chlorinated hydrocarbons, and tobacco chemical mixture, that may impact fetal immune status, and their joint effect upon childhood acute lymphoblastic leukemia (ALL) risk; Project 2 (Identifying In Utero Exposures that are Risk Factors for Childhood Leukemia) will characterize broad classes of maternal/fetal exposures received during gestation from diverse sources including pollution, diet, drugs and endogenous processes by conducting untargeted omics examinations of small molecules and of adducts of reactive electrophiles; Project 3 (Prenatal Exposures, Constitutive Genetics, DNA Methylation & Childhood Leukemia) will provide a clearer understanding of combined impact of both environmental and genetic causes and immune factors on DNA methylation patterns in childhood leukemia, using neonatal blood spots; the Community Outreach and Translation Core (COTC; Core B) will disseminate findings from each Project to various audiences who share interest in the etiology of childhood leukemia; and Mouse Model Service Core (Core C) will test the impact of chemical exposures in an animal model of pediatric acute lymphoblastic leukemia. The main objectives of Core A are to provide oversight, coordination, and integration of Center activities; establish/manage an External Advisory Committee; coordinate community engagement, appoint and collaborate with the Pediatric Health Specialist, and support the research career development of new Career Development Investigator within the structure of the Center. Pursuant to these objectives, Core A will provide centralized administrative and research support to all Projects and Cores.