Core C: Data Coordinating Core

摘要 数据核心的使命是加速中心的沟通、进步和共享。《核心》 实现这些目标的活动将分布在三个主要领域，与三个具体目标相对应 目标：1)促进中心内部的沟通、协作和共享，通过建立 用于数据共享、质量和完整性检查以及存储的基础架构；2)与合作分析数据 中心调查人员和其他核心，通过使用一系列算法进行数据分析，范围从标准 对先进的、基于网络的多维集成方法的差异表达分析 数据集；3)通过以下方式与研究社区共享中心生成的高通量数据 使用政府和非政府资助的公共数据库。通过与所有项目和 作为核心，数据核心将为数据分析和中心内通信提供关键基础设施。通过 为公共资料库贡献数据，这些数据是在有价值的紧张症细胞模型中生成的--以及来自患者的数据 随着神经退化项目和核心的出现，数据核心将在传播 由整个中心产生的知识。

SUMMARY The mission of the Data Core is to accelerate the Center's communication, progress, and sharing. The Core activities towards these goals will be distributed across three main areas, corresponding to the three Specific Aims: 1) to facilitate communication, collaboration, and sharing within the Center, by establishing an infrastructure for data sharing, quality and integrity checks, and storage; 2) to analyze data in collaboration with Center Investigators, and other Cores, by using a series of algorithms for data analysis, ranging from standard differential expression analysis to advanced, network-based methods for integration of multidimensional datasets; 3) to share high-throughput data generated by the center with the research community through the use of government and nongovernment-sponsored public databases. By interacting with all Projects and Cores, the Data Core will provide a key infrastructure for data analysis and intra-Center communication. By contributing to public repositories data generated in valuable cellular models of tauopathy – and from patients with neurodegeneration – in Projects and Cores, the Data Core will play a key role in disseminating the knowledge generated by the entire Center.