Cancer Immunology Training Grant

项目摘要 该培训计划旨在培训达纳大学的下一代癌症免疫学科学家- 法伯/哈佛癌症中心，一家哈佛大学范围内的、NCI指定的综合癌症中心。近期 临床试验表明，癌症免疫疗法可以在患有癌症的患者中诱导持久的反应。 各种类型的晚期癌症。免疫细胞靶向单一抑制性受体的发现 能否释放持久的抗肿瘤免疫对肿瘤学有着深远的影响，并引发了许多 关于调节抗肿瘤免疫的生物机制的有趣问题。由此产生的快速 癌症免疫学领域的发展产生了对具有深入专业知识的科学家的重大需求 免疫学与肿瘤生物学的接口。为了满足这一需求，我们建立了一个全面的计划 由在基础和转化性癌症免疫学方面提供广泛专业知识的教职员工支持。这个 这一赠款的受赠人对癌症免疫学和 免疫疗法。我们建议每年任命2名博士后和6名博士后科学家。我们的博士前 学员将从已注册免疫学和基础生物医学的学生中挑选出来 哈佛医学院理科研究生课程。这些学生将在第二年毕业后被任命。 一年的学习一旦他们选择了我们的一位导师作为他们的论文导师并致力于研究 癌症免疫学专题。博士后职位将授予选定的近期获奖者 博士和医学/博士学位，并支持他们在癌症免疫学方面的培训。癌症实验室培训 作为免疫学的补充，还将有一个教学计划，为学生提供所需的 癌症免疫学，并为他们在学术研究、生物技术或 广泛的其他工作机会。项目负责人高度致力于教学和指导 并拥有领导这项工作所需的专业知识。博士后和研究生事务办公室 Dana-Farber和哈佛医学院为我们所有的实习生提供了广泛的课程，旨在 增强他们的培训经验，满足个人需求。哈佛大学组织的务虚会 Dana-Farber的免疫学计划和癌症免疫和病毒学系将帮助 营造社区意识，让学员有机会向其他学员和教职员工学习。

Project Summary This training program is designed to train the next generation of scientists in Cancer Immunology at the Dana- Farber/Harvard Cancer Center, a Harvard-wide, NCI-designated Comprehensive Cancer Center. Recent clinical trials have demonstrated that cancer immunotherapy can induce durable responses in patients with diverse types of advanced cancer. The discovery that targeting of a single inhibitory receptor on immune cells can unleash durable anti-tumor immunity has far-reaching implications for oncology and raises many fascinating questions about the biological mechanisms that regulate anti-tumor immunity. The resulting rapid growth in the field of cancer immunology has created a significant need for scientists with in depth expertise at the interface of immunology and tumor biology. To address this need, we have built a comprehensive program supported by faculty who bring a wide spectrum of expertise in basic and translational cancer immunology. The preceptors of this grant have made a series of important contributions to cancer immunology and immunotherapy. We propose to appoint 2 predoctoral and 6 postdoctoral scientists per year. Our predoctoral trainees will be selected from a pool of students who have enrolled in the Immunology and Basic Biomedical Sciences Graduate Programs at Harvard Medical School. These students will be appointed after their second year of study once they have chosen one of our mentors as their thesis advisor and committed to a research topic in cancer immunology. The postdoctoral positions will be awarded to a select group of recent recipients of PhD and MD/PhD degrees and support their training in cancer immunology. Laboratory training in cancer immunology will be complemented by a didactic program that gives students the required background in cancer immunology and prepares them for independent careers in academic research, biotechnology or a broad range of other job opportunities. The program directors are highly committed to teaching and mentoring and have the required expertise to lead this effort. The Postdoctoral and Graduate Student Affairs Offices at Dana-Farber and Harvard Medical School provide a wide range of programs to all of our trainees designed to enhance their training experience and address individual needs. Retreats organized by the Harvard Immunology Program and the Department of Cancer Immunology and Virology at Dana-Farber will help to create a sense of community and give our trainees the opportunity to learn from other trainees and faculty.