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Redox homeostasis in cancer and cardiovascular diseases

Redox homeostasis in cancer and cardiovascular diseases
癌症和心血管疾病中的氧化还原稳态
批准号：
9550549
负责人：
PAUL M. HWANG
金额：
$61.99万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9550549
关键词：
AffectBiologicalBiologyCardiovascular DiseasesCardiovascular systemDNA DamageDiseaseEnergy MetabolismGenerationsGeneticGenomic DNAHomeostasisMalignant NeoplasmsMethodsOxidation-ReductionOxidative StressOxygenPathogenesisReactive Oxygen SpeciesStressmitochondrial dysfunctionneoplastic celltumorigenesis

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中文摘要
翻译
我们之前的研究表明，线粒体功能障碍导致氧化性基因组DNA损伤，并有助于肿瘤的发生。一个主要的影响因素是环境氧，它是产生活性氧的基本底物，可引起生物损伤。环境和遗传方法将用于调节氧化还原稳态，并确定其对能量代谢、肿瘤发生和心血管疾病的影响。我们正在研究肿瘤细胞或心血管细胞在氧化或其他毒性应激条件下存活的适应机制。
英文摘要
Our previous studies have suggested that mitochondrial dysfunction causes oxidative genomic DNA damage and contributes to tumorigenesis. A major contributing factor is ambient oxygen which is the essential substrate for reactive oxygen species generation that can cause biological damage. Environmental and genetic methods will be used to modulate redox homeostasis and to determine their effect on energy metabolism, tumorigenesis, and cardiovascular disease. We are examining adaptive mechanisms by which cells of neoplastic or cardiovascular origin survive under oxidative or other toxic stress conditions.
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Genetic insights into mitochondrial function, cancer and cardiovascular diseases
Effects of redox homeostasis on cancer and cardiovascular diseases
Genetic insights into cardiovascular function and disease
Redox homeostasis in cancer and cardiovascular diseases
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