DNA Replication and Recombination

摘要 请求为题为DNA复制和重组的Keystone研讨会会议提供支持， 由John F.X Diffley博士、Anja Groth博士和Scott Keeney博士组织。会议将在圣达菲举行， 2017年4月2日至6日在新墨西哥州举行。DNA复制和重组在所有细胞中都是常见的。这些错误中的错误 这一过程会导致人类患上许多疾病，包括癌症，但许多基本问题仍然存在 悬而未决。由于显微镜和其他技术的最新技术进步，这些动态过程 现在在原核生物和真核生物中都可以在时间和空间上进行研究。此外，在这一领域的突破 DNA复制、重组修复和单粒子过程的生化重构 电子显微镜有望在近原子分辨率下揭示新的机制；以及新的DNA测序 技术使我们有可能非常详细地研究这些关键过程。机械上的相似之处 生活的三个领域提供了新的基本原则，而差异则确定了潜在的治疗目标 干预。该系列历来是该领域的首屈一指的会议之一，也是非常 很少有哪种生物能将从事复制和重组工作的科学家聚集在一起，研究所有生命形式。因为. DNA复制和重组之间的密切关系及其对基因组稳定性的重要性， 本次会议将与关于基因组不稳定和DNA的Keystone研讨会联合举行 修理。在DNA复制和重组会议上的演讲将集中在机制和 对这些过程的监管，重点是多个有机体和多种方法。联合会谈 会议将集中在停滞不前的复制分叉的新陈代谢和染色质在 复制、重组和基因组稳定性。

ABSTRACT Support is requested for a Keystone Symposia conference entitled DNA Replication and Recombination, organized by Drs. John F.X. Diffley, Anja Groth and Scott Keeney. The conference will be held in Santa Fe, New Mexico from April 2-6, 2017. DNA replication and recombination are common to all cells. Errors in these processes lead to many diseases in humans, including cancer, and many fundamental questions are still unresolved. Due to recent technical advances in microscopy and other techniques, these dynamic processes can now be studied in time and space in both prokaryotes and eukaryotes. Moreover, breakthroughs in the biochemical reconstitution of processes in DNA replication and recombination repair as well as single particle electron microscopy promise to reveal new mechanisms at near-atomic resolution; and new DNA sequencing technologies make it possible to study these key processes in great details. Mechanistic similarities across the three domains of life provide new basic principles while differences identify potential targets for therapeutic intervention. This series has historically been one of the premiere conferences in this field and one of the very few that brings together scientists working in replication and recombination across all life forms. Because of the close relationship between DNA replication and recombination and their importance for genome stability, this conference will be held jointly with the Keystone Symposia conference on Genomic Instability and DNA Repair. Talks at the DNA Replication and Recombination conference will focus on the mechanism and regulation of these processes, with an emphasis on multiple organisms and multiple approaches. Talks in joint sessions will center on the metabolism of stalled replication forks and the importance of chromatin in replication, recombination and genome stability.