Interdisciplinary and Translational Research Training in NeuroHIV

摘要： 这项相互竞争的续期申请为继续和进一步发展 面向博士前学生的“神经HIV跨学科和转化性研究培训计划” 研究HIV感染的中枢神经系统(CNS)并发症及相关领域的研究。这是一个 由坦普尔大学和德雷克塞尔大学两所机构联合开设的课程，该课程位于 宾夕法尼亚州费城。该计划还整合了培训活动和 坦普尔大学和德雷克塞尔大学的神经艾滋病综合中心(CNAC)和一个 艾滋病与神经病毒学科室临床研究培训项目的关系 医学、微生物学和神经病学以及其他临床和基础科学系和中心 宾夕法尼亚大学艾滋病研究(CFAR)。我们正在进行的项目将继续发展 我们的全市跨学科和转化性研究培训计划通过共享 资源、联合研讨会、讲习班、座谈会、特邀演讲者以及论文指导和教育 坦普尔和德雷克塞尔都提供活动。这两所大学的研究生课程都是为了 在生物医学方面提供广泛的科学基础，包括神经科学、免疫学、 微生物学、药理学和生理学。本课程包括负责任的研究行为， 科学通信、统计以及高级课程，深入培训分子和 细胞神经生物学、神经发病机制和翻译神经科学。这个节目汇集了 多个生物医学基础科学部门，整合两个相邻的联合培训活动 调查人员之间具有独特和长期合作关系的机构(坦普尔和德雷克塞尔)位于 宾夕法尼亚大学紧邻德雷克塞尔大学。纳入获得临床艾滋病毒的机会 翻译学生研究项目的调查人员，以及Temple/Drexel CNAC基础科学和 临床核心设施极大地增强了我们的培训计划的跨学科性质。它还 让学生了解基础科学和临床观点的相互关联性，重点是艾滋病毒和中枢神经系统 功能障碍、共病情况(如衰老、药物滥用、共感染病原体、癌症)、艾滋病毒疫苗 和预防策略，以及治疗和治愈艾滋病毒感染的新的神经保护和治疗策略 在外围和储藏室，包括大脑。我们的联合训练计划，连同我们的联合 通过我们的CNAC提供的基础设施资源，提供了一个强大、交互且非常成功的 费城地区的神经病毒学和神经艾滋病毒培训环境。为了支持和 在这项计划中加强我们代表不足的少数族裔的招聘我们将继续提供暑期 对医学生和卫生专业的学生进行实验室培训，包括毕业后 学士学位学生将为进入我们的博士和医学博士/博士培训计划提供途径 在神经艾滋病方面。

ABSTRACT: This competing renewal application provides a plan for the continuation and further development of the “Interdisciplinary and Translational Research Training Program (ITRTP) in NeuroHIV” for predoctoral students studying central nervous system (CNS) complications of HIV infection and related areas of research. This is a joint program from two institutions, Temple University and Drexel University, located in close proximity in Philadelphia, Pennsylvania. This program also integrates training activities and research resources available in the Comprehensive Center for NeuroAIDS (CNAC) involving both Temple and Drexel University and a relationship with the clinical research training programs in HIV and Neurovirology based in the Departments of Medicine, Microbiology, and Neurology as well as other clinical and basic science departments and the Center for AIDS Research (CFAR) at the University of Pennsylvania. Our ongoing program will continue to develop our citywide interdisciplinary and translational research training program in NeuroHIV through shared resources, joint seminars, workshops, symposia, invited speakers, as well as thesis mentoring and educational activities available at both Temple and Drexel. The graduate curriculum at both institutions is designed to provide a broad-based scientific foundation in biomedical sciences, including neuroscience, immunology, microbiology, pharmacology and physiology. This curriculum includes responsible conduct of research, scientific communication, statistics, as well as advanced courses with in-depth training in molecular and cellular neurobiology, neuropathogenesis, and translational neuroscience. This program brings together multiple biomedical basic science departments and integrates joint training activities at two neighboring institutions (Temple and Drexel) with unique and long-standing relationships between investigators located at the University of Pennsylvania positioned immediately adjacent to Drexel. Inclusion of access to clinical HIV investigators in translational student research projects, as well as Temple/Drexel CNAC basic science and clinical core facilities greatly enhances our training program with respect to its interdisciplinary nature. It also exposes students to the interrelatedness of basic sciences and clinical perspectives focusing on HIV CNS dysfunction, co-morbid conditions (i.e. aging, substance abuse, co-infecting pathogens, cancer), HIV vaccine and prevention strategies, and novel neuroprotective and therapeutic strategies to treat and cure HIV infection in the periphery and reservoirs including the brain. Our joint training program, together with our joint infrastructural resources available through our CNAC, provides a strong, interactive, and highly successful training environment in neurovirology and neuroHIV within the Philadelphia region. In order to support and enhance our under-represented minority recruitment within this program we will continue to provide summer laboratory training of medical students, and students in health professional programs including post- baccalaureate students that would provide pathways for entry into our Ph.D. and M.D./Ph.D. training program in NeuroHIV.