Training Program in Cardiometabolic Diseases

项目摘要 这是Ruth L.Kirschstein国家研究机构的第二次竞争性续签申请 服务奖(T32)，最初设立于2009年，旨在提供密切指导的多学科 对有前途的内科科学家和博士进行博士后研究培训，为他们的职业生涯做好准备 作为独立的心血管研究人员。自成立以来，我们共招收了18名学员， 其中包括两个代表性不足的少数民族。我们项目的几乎所有毕业生都做出了重大贡献 到心血管文献，有相当比例的人获得了全日制学术或行业 从事生物医学研究的职位。该项目的四名毕业生已被招募到 我们心内科的教员作为全职内科研究员和所有人都成功地参加了 独立的NIH或AHA资助。在这个相互竞争的续订申请中，有两个主要的变化。第一, 反映了纽约大学医学院研究心血管并发症的教职员工队伍不断壮大 糖尿病和代谢紊乱以及我们心脏科和心内科研究的紧密整合 内分泌学，在这次更新中，我们将T32更名为心脏代谢性疾病培训计划 并任命内分泌学主任Ira Goldberg博士担任联合项目主任(PD)。第二, 作为实施ABIM研究路径和临床研究人员的预期结果 进入我们的内科住院医师计划，我们有越来越多的高才华的MD和 博士/博士研究员寻求强化博士后研究培训计划作为其目标的下一步 开展独立研究事业。因此，我们要求扩展此T32培训 计划每年增加到六个职位。与过去一样，培训计划是建立在高度 有成就和经验的美国国立卫生研究院资助的初级教员。这门课程包括严格的 教学方法、个性化的指导计划和密集的研究体验。培训计划开始 拥有基础广泛的教育课程，为所有学员提供基本的知识基础， 强调研究工具以及生物医学研究与疾病重要表现之间的接口 心血管疾病。然后，学员将学习更专业的课程，并开始进行实质性的 在初级导师的指导下，在以下几个领域之一的实验室或临床研究项目 机构优势：心肌/离子通道生物学与疾病；血管生物学与疾病；代谢 心血管疾病的病因和临床研究。鉴于我们的过往记录，我们有信心 对这一项目的持续支持将产生一批才华横溢、积极进取的调查人员 他们致力于加强美国和其他地方的心血管/心脏代谢健康。

PROJECT ABSTRACT This is the second competing renewal application for a Ruth L. Kirschstein Institutional National Research Service Award (T32), which was originally established in 2009 to provide closely mentored, multidisciplinary postdoctoral research training to highly promising physician-scientists and PhDs and prepare them for careers as independent cardiovascular investigators. Since its inception, we have enrolled a total of eighteen trainees, including two under-represented minorities. Almost all graduates of our program have contributed significantly to the cardiovascular literature and a substantial proportion have obtained full-time academic or industry positions engaged in biomedical investigation. Four graduates of the program have been recruited to the faculty of our Division of Cardiology as full-time physician-investigators and all have competed successfully for independent NIH or AHA funding. There are two major changes in this competing renewal application. First, reflecting the growing cadre of faculty at NYU School of Medicine investigating cardiovascular complications of diabetes and metabolic disorders and the tight integration of research in our Divisions of Cardiology and Endocrinology, in this renewal we have renamed this T32 the Training Program in Cardiometabolic Diseases and have named Dr. Ira Goldberg, Director of Endocrinology to the role of co-Program Director (PD). Second, as an anticipated consequence of implementing the ABIM Research Pathway and Clinical Investigator Pathway into our Internal Medicine residency program, we have a growing pipeline of highly talented MD and MD/PhD fellows seeking intensive postdoctoral research training program as the next step in their goal of launching independent research careers. Therefore, we are requesting an expansion of this T32 training program to six positions each year. As in the past, the training program is built upon a foundation of highly accomplished and experienced NIH-funded primary faculty members. The curriculum includes rigorous didactics, a personalized mentoring plan, and an intensive research experience. The training program begins with a broad-based educational curriculum that provides all trainees with a fundamental knowledge-base that stresses research tools and the interface between biomedical research and important manifestations of cardiovascular disease. Trainees will then pursue more specialized coursework and embark upon a substantial laboratory-based or clinical research project under the guidance of a Primary Mentor in one of several areas of institutional strength: Myocardial/Ion Channel Biology and Disease; Vascular Biology and Disease; Metabolic Causes of Cardiovascular Disease, and Clinical Research. Given our track-record, we are confident that continued support for this program will produce a steady pipeline of highly talented and motivated investigators who are committed to enhancing cardiovascular/cardiometabolic health in the United States and elsewhere.