Biospecimen Shared Resource

生物标本共享资源：摘要 生物标本共享资源（BSR），由安德鲁K。Godwin，PhD（BSR创始董事;副董事 主任，KUCC，和D3 ET成员），并由Rashna Madan，MBBS，FCAP，FASCP（助理主任， BSR），在堪萨斯大学癌症中心（KUCC）发挥着至关重要的作用，其道德收集，储存， 注释和分发高质量的人类生物标本，如新鲜/新鲜冷冻的肿瘤组织， 不同的组织学和体液（例如，血液、骨髓、唾液、尿液、腹水），这是必不可少的 以支持转化研究和翻译发起的研究。BSR还提供专家 组织病理学支持，并结合病理学家，转化研究人员和技术人员的专业知识， 人员产生一个全面的和重点突出的方法，以支持在KUCC的研究活动。的 BSR在2017年被评为“卓越到杰出”，继续发展，以满足不断扩大和多样化的需求。 我们的KUCC成员对高度注释的临床样本的需求。此外，组织生物标本采集 由KU医院和Indian Creek校区的病理学助理、住院医师和研究员提供便利 (ICC)作为堪萨斯大学卫生系统（TUKHS）对BSR承诺的一部分。BSR完全 配备生物标本采集、处理和分发，因此，BSR符合OSHA 处理冷冻剂的实验室标准、ISBER储存库最佳实践和NCI 生物标本资源，并制定了标准操作程序，以管理每一个这些 流程.生物样品研究所的工作人员对标本的收集、处理和分发有了很大的增长 在资助期间，现在包括ICC和儿童慈善机构的儿科标本收藏 (CM)和杜鲁门医学中心（TMC）卫星生物标本库中服务不足的人群， 共济会癌症联盟（MCA）的成员和堪萨斯城最大的安全网提供者 大都会区。自2011年成立CCSG BSR以来，我们已经招募了51，916名知情人士， 支持了4，795名参与者的银行业务，以进行研究员发起的研究，从而定期使用de- 已识别的生物样本和匹配的临床数据。在当前的赠款周期（2016-2020年），BSR 提供关键服务，支持150篇出版物（57篇影响因子≥ 10），96个独特的癌症中心 成员，以及>35 NIH/NIGMS/NCI赠款和合同，包括1 K 01，1 R 00，12 R 01，1 R 03，6 R21，1 R33、1 R35、2 R43、2 P20、1 P30、1 P41、2 U 01、TCGA 13 XS 194和CPTAC 14 X215、16 x257、19 x139和311 临床试验在报告年度（2020年），BRS支持82个不同的用户（54个KUCC成员） 三个项目，其中85%得到资助，28个非成员，包括16名癌症研究人员 国）。BSR（第11年）的拟议预算为1，511，949美元，而CCSG的请求为118，342美元。作为 因此，BSR利用赠款、合同、用户费用和广泛的机构支持，只寻求7.8%的资金， CCSG基金的支持。

BIOSPECIMEN SHARED RESOURCE: ABSTRACT The Biospecimen Shared Resource (BSR), led by Andrew K. Godwin, PhD (Founding Director, BSR; Deputy Director, KUCC, and D3ET member), and by Rashna Madan, MBBS, FCAP, FASCP (Assistant Director, BSR), plays a vital role in The University of Kansas Cancer Center (KUCC) by its ethical collection, storage, annotation, and distribution of high-quality human biospecimens, such as fresh/fresh-frozen tumor tissues of varying histology and bodily fluids (e.g., blood, bone marrow, saliva, urine, ascites fluids), which are essential to support translational research and investigator-initiated studies. The BSR also provides expert histopathology support and combines the expertise of pathologists, translational researchers, and technical personnel to produce a comprehensive and focused approach to support the research activities at KUCC. The BSR, rated “exceptional to outstanding” in 2017, continues to evolve to meet the ever-expanding and diverse needs of our KUCC members for highly annotated clinical samples. Additionally, tissue biospecimen collection is facilitated by pathology assistants, residents and fellows at the KU Hospital and the Indian Creek Campus (ICC) as part of The University of Kansas Health System’s (TUKHS) commitment to the BSR. The BSR is fully equipped for biospecimen collection, processing, and distribution, and thus, the BSR adheres to the OSHA laboratory standards for handling cryogens, ISBER Best Practice for Repositories, and NCI Best Practices for Biospecimen Resources, and has developed Standard Operating Procedures to govern each of these processes. The collection, processing, and distribution of specimens by the BSR staff has grown substantially over the funding period and now includes collections of pediatric specimens from ICC and Children’s Mercy (CM) and underserved populations from the satellite biospecimen bank at Truman Medical Center (TMC), a member of the Masonic Cancer Alliance (MCA) and the largest safety-net provider in the Kansas City Metropolitan area. Since founding the CCSG BSR in 2011, we have enrolled 51,916 consented individuals and supported the banking of 4,795 participants for investigator-initiated studies resulting in regular usage of de- identified biospecimens and matching clinical data. During the current grant cycle (2016-2020), the BSR provided key services in support of 150 publications (57 papers ≥ 10 impact factor), 96 unique cancer center members, and >35 NIH/NIGMS/NCI grants and contracts including, 1 K01, 1 R00, 12 R01s, 1 R03, 6 R21s, 1 R33, 1 R35, 2 R43, 2 P20, 1 P30, 1 P41, 2 U01, TCGA 13XS194, & CPTAC 14X215, 16x257, 19x139 and 311 clinical trials. In the reporting year (2020), the BRS supported 82 different users (54 KUCC members across all three programs, of which 85% were funded and 28 non-members, including 16 cancer-focused researchers nationally). The proposed budget of the BSR (year 11) is $1,511,949, yet the CCSG request is $118,342. As such, the BSR leverages grants, contracts, user fees, and extensive institutional support and seeks only 7.8% support from CCSG funds.